Anna Dimberg – Tumor vascular biology

The focus of our research is to understand how the vasculature affects cancer progression through regulation of the tumour microenvironment.

Blood vessel formation and inflammation are closely linked processes that affect the clinical outcome of several pathological conditions, including cancer. Endothelial cells, lining the inside of vessels, are central players in both these processes. They initiate the formation of new vessels after growth factor stimulation and regulate extravasation of inflammatory cells from the blood stream into the tissue.

Tumor vessels are morphologically and functionally distinct from normal vessels, at least partially as a consequence of ongoing angiogenesis and extensive growth factor stimulation. Proteins specifically expressed in endothelial cells during tumor angiogenesis may constitute new targets for cancer treatment. Importantly, heterogeneous protein expression in tumor endothelium may affect leukocyte recruitment, permeability and establishment of a vascular niche.

 

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photo: microscope image of blood vessel