Student projects at IGP

IGP offers projects for students in different education programmes. Below you can find summaries of currently available projects in the research areas cancer/oncology, vascular biology, molecular tools, genetics and genomics, pathology, radiation sciences and immunology.

Click on the title of the project you are interested in to get a more detailed description. Reach out to the respective supervisor with the help of the provided contact details.  

Are you a researcher and would like to announce a project?  Please contact hanne.demaeyer@igp.uu.se

Project courses

Project courses at IGP are offered as 7.5, 15 or 30 credit courses. 

For students interested in these courses: 
Please apply by filling in the Project Agreement. Note that you have to agree on a project with your supervisor to be eligible for the course. Apply for the course at antagning.se. Do not forget to upload the filled form with your application. 

If you - as a supervisor - accept a project student or intern, please follow the instructions outlined in the Procedure for student projects and unpaid internships at IGP, before the person is registered in Columbus.

Projects in the research area cancer/oncology

Extracellular matrix interactions of importance for brain tumor formation

In our projects we incorporate experience of neural stem cells with glioma biology, leveraging the close relationship between these two fields. We focus on the tumor microenvironment with special emphasis on the extracellular matrix and the neuro-inflammatory responses to brain tumors.

Functional understanding and use of molecular markers of cancer development for diagnostics and treatment

We are looking for students interested in improving treatment and diagnostics for cancer. Our projects include various opportunities for improving your skills in e.g. bioinformatics, cell culture-based assays, genomics, proteomics and wet lab techniques.

  1. Genomic analysis of a large cohort of colorectal cancer cases
  2. Biomarker discovery for early detection of cancer
  3. Development of novel personalized cancer therapies

Clinical or translational research on adult cancer cases in U-CAN

Opportunity for students to work with clinical data or sample analyses based on the cancer cases included in U-CAN for hypothesis testing.

Spatial analysis of immune microenvironment in solid tumors

The effect of anti-tumor immunotherapy is very heterogeneous and only a minor fraction of patients benefits from this therapy. We are applying in situ visualization technology to characterize immune infiltrate in major solid cancers and investigate infiltration patterns of different immune cell classes, enabling a detailed classification of different tumor types according to their immunological status.

The role of the lymph node vasculature in tumour metastasis and anti-tumour immunity

The lymph nodes have essential roles in adaptive immune responses, including antitumour immune responses, and are major sites for tumour metastasis. Our group is interested in the stromal changes that occur in the tumour draining lymph nodes and particularly the changes of the vasculature and how this affect tumour metastasis and anti-tumour immune responses.

Identification of long non-protein-coding RNAs collaborating with PRC2 in MM

Multiple myeloma (MM) despite becoming increasingly treatable remains to date incurable and accounts for the second most common hematological cancer. This warrants innovative approaches into tackling the disease overtly complex genetic background. Our research aims is to identify interacting partners with the Polycomb group proteins by RNA immunoprecipitation coupled with next generation sequencing (RIP-seq, CLIP seq or iCLIP) in MM cell lines and primary MM samples. We also aim to identify the genome-specific binding of lncRNAs of interest by chromatin isolation via RNA precipitation (ChIRP) assays coupled to next generation sequencing and mass spectrometry. 

Investigations of cancer stem cells in the brain cancer glioblastoma

Glioblastoma is the most common and deadly primary brain cancer. Our research aims at identifying mechanisms governing progression and recurrence, with focus on the cancer stem cells. We use patient-­‐derived cell cultures and mouse models, and the goal is to find novel therapeutic targets in glioblastoma.

Understanding the role of lysosome biogenesis and turnover in cancer

Lysosomes are acidic organelles that degrade macromolecules and have often been viewed as basic “trashcans” of cells. In recent years however, it has become clear that lysosomes function as crucial gate-keepers of cell growth and cancer. This is largely due to the surprising finding that the principal regulators of anabolic metabolism specifically locate to the lysosomal surface (1,2,3). An aberrant increase in lysosome number and abundance frequently accompanies malignant cells (4), yet it remains unclear how these changes rewire anabolic metabolism and the growth-potential of cancer cells

New treatment for glioblastoma: Regulation of general resistance mechanisms and opportunities for development of new therapeutic protocols.

Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. The cancer cells vary between more treatment-resistant and more treatment-sensitive cell-states. Current studies aim to uncover forces that drives these phenotypically linked cell-state transitions changes to develop efficient treatment.

Projects in the research area Molecular Tools

New approaches for molecular diagnostics

Molecular diagnostics will increasingly impact medical practice. Our group develops, applies, and commercializes advanced molecular tools for diagnostic analyses of nucleic acids and proteins in situ and in solution. We welcome students interested in medical applications of the methods.

Development of novel epigenomic profiling techniques

In this project, we would like to develop novel molecular tools based on transposase-accessible chromatin using sequencing (ATAC-seq) and explore the potential application in clinical samples. Highly-motivated students with a strong communication and trouble-shooting skills are welcome to join us.

Projects in the research area Immunology

Understanding the biological mechanisms of autologous hematopoietic stem cell transplantation in the treatment of multiple sclerosis.

Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system, and the most common cause of neurological disability in young adults. One available treatment for MS is autologous hematopoietic stem cell transplantation (AHSCT), where bone marrow stem cells are collected from the patient and re-infused after immune cell-depleting treatment with cytotoxic drugs. This is thought to “reset” the immune system. In our group, neurologists and immunologists are working in close collaboration to understand the mechanisms behind the therapeutic effect.

Last modified: 2021-07-05