IGP researchers receive million SEK grant from the Knut and Alice Wallenberg Foundation
Lena Claesson-Welsh, Christer Betsholtz, Elisabetta Dejana, Taija Mäkinen and Michael Simons are awarded SEK 38 million during five years to characterise blood and lymphatic vessels in different organs. The characterisation can provide the basis for targeted analyses and improved therapies specifically for what is unique for each vessel type.
The body’s blood and lymphatic vessels have some overall functions in common but they also have a set of organ-specific features. However, information is lacking on how the vessels are structured in different organs, what makes them acquire their specific features and how this contributes to the organs’ various functions.
In the funded project the researchers will determine the structure and function of blood and lymphatic vessels in three very different organs, the central nervous system (CNS), the skin and the aorta. They will map what is common, but also what is unique, for the different vessels. They will also apply the obtained structural and functional maps on a number of severe diseases that affect the vessels on the CNS, skin and aorta.
“It is wonderful to receive this support for our research on organ-specific similarities and differences in blood and lymphatic vessels. The project will provide reference information on RNA and protein level but also a basis for organ-specific stimulation or inhibition in for instance diseases that engage the vascular system. We will make our very best of this support,” says Lena Claesson-Welsh, main applicant in the granted application.