Publications in DiVA – Magnus Essand

CD4⁺ T cell-induced inflammatory cell death controls immune-evasive tumours

Kruse, Bastian; Buzzai, Anthony C.; Shridhar, Naveen; Braun, Andreas D. et al.

Part of Nature, p. 1033-1040, 2023.

DOI for CD4⁺ T cell-induced inflammatory cell death controls immune-evasive tumours Download full text (pdf) of CD4⁺ T cell-induced inflammatory cell death controls immune-evasive tumours

Complementarity-determining region clustering may cause CAR-T cell dysfunction

Sarén, Tina; Saronio, Giulia; Marti Torrell, Paula; Zhu, Xu et al.

Part of Nature Communications, 2023.

DOI for Complementarity-determining region clustering may cause CAR-T cell dysfunction Download full text (pdf) of Complementarity-determining region clustering may cause CAR-T cell dysfunction

Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer

Vaccaro, Alessandra; van de Walle, Tiarne; Ramachandran, Mohanraj; Essand, Magnus et al.

Part of Frontiers in Immunology, 2023.

DOI for Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer Download full text (pdf) of Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer

Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran, Mohanraj; Vaccaro, Alessandra; van de Walle, Tiarne; Georganaki, Maria et al.

Part of Cancer Cell, p. 1134-1151, 2023.

DOI for Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma Download full text (pdf) of Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

Jin, Chuan; Ma, Jing; Ramachandran, Mohanraj; Yu, Di et al.

Part of Nature Biomedical Engineering, p. 830-841, 2022.

DOI for CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers Download full text (pdf) of CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation

Konstantinidis, Evangelos; Molisak, Agnieszka; Perrin, Florian; Streubel-Gallasch, Linn et al.

Part of Molecular Therapy Nucleic Acids, p. 450-461, 2022.

DOI for CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation Download full text (pdf) of CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation

Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-turnor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response

Jin, Chuan; Ali, Arwa; Iskantar, Alexandros; Fotaki, Grammatiki et al.

Part of Oncoimmunology, 2022.

DOI for Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-turnor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response Download full text (pdf) of Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-turnor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response

Ixovex-1, a novel oncolytic E1B-mutated adenovirus

Anwar, Mohiemen; Arendt, Maja-Louise; Ramachandran, Mohanraj; Carlsson, Anette et al.

Part of Cancer Gene Therapy, p. 1628-1635, 2022.

DOI for Ixovex-1, a novel oncolytic E1B-mutated adenovirus Download full text (pdf) of Ixovex-1, a novel oncolytic E1B-mutated adenovirus

Targeting circulating monocytes with CCL2-loaded liposomes armed with an oncolytic adenovirus

Iscaro, Alessandra; Jones, Christian; Forbes, Neil; Mughal, Amina et al.

Part of Nanomedicine, 2022.

DOI for Targeting circulating monocytes with CCL2-loaded liposomes armed with an oncolytic adenovirus

Whole body FDG PET/MR for progression free and overall survival prediction in patients with relapsed/refractory large B-cell lymphomas undergoing CAR T-cell therapy

Sjöholm, Therese; Korenyushkin, Alexander; Gammelgård, Gustav; Sarén, Tina et al.

Part of Cancer Imaging, 2022.

DOI for Whole body FDG PET/MR for progression free and overall survival prediction in patients with relapsed/refractory large B-cell lymphomas undergoing CAR T-cell therapy Download full text (pdf) of Whole body FDG PET/MR for progression free and overall survival prediction in patients with relapsed/refractory large B-cell lymphomas undergoing CAR T-cell therapy

ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression

Darweesh, Mahmoud; Younis, Shady; Hajikhezri, Zamaneh; Ali, Arwa et al.

Part of Frontiers in Immunology, 2022.

DOI for ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression Download full text (pdf) of ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression

Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

van Hooren, Luuk; Vaccaro, Alessandra; Ramachandran, Mohanraj; Vazaios, Konstantinos et al.

Part of Nature Communications, 2021.

DOI for Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma Download full text (pdf) of Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

Development of a New Hyaluronic Acid Based Redox-Responsive Nanohydrogel for the Encapsulation of Oncolytic Viruses for Cancer Immunotherapy

Deng, Siyuan; Iscaro, Alessandra; Zambito, Giorgia; Mijiti, Yimin et al.

Part of Nanomaterials, 2021.

DOI for Development of a New Hyaluronic Acid Based Redox-Responsive Nanohydrogel for the Encapsulation of Oncolytic Viruses for Cancer Immunotherapy Download full text (pdf) of Development of a New Hyaluronic Acid Based Redox-Responsive Nanohydrogel for the Encapsulation of Oncolytic Viruses for Cancer Immunotherapy

IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma

Martikainen, Miika; Ramachandran, Mohanraj; Lugano, Roberta; Ma, Jing et al.

Part of MOLECULAR THERAPY-ONCOLYTICS, p. 37-46, 2021.

DOI for IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma Download full text (pdf) of IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma

Perivascular macrophages regulate blood flow following tissue damage

Vågesjö, Evelina; Parv, Kristel; Ahl, David; Seignez, Cedric et al.

Part of Circulation Research, p. 1694-1707, 2021.

DOI for Perivascular macrophages regulate blood flow following tissue damage

Tertiary Lymphoid Structures in the Central Nervous System: Implications for Glioblastoma

van de Walle, Tiarne; Vaccaro, Alessandra; Ramachandran, Mohanraj; Pietilä, Ilkka et al.

Part of Frontiers in Immunology, 2021.

DOI for Tertiary Lymphoid Structures in the Central Nervous System: Implications for Glioblastoma Download full text (pdf) of Tertiary Lymphoid Structures in the Central Nervous System: Implications for Glioblastoma

Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson's disease brain

Rostami, Jinar; Fotaki, Grammatiki; Sirois, Julien; Mzezewa, Ropafadzo et al.

Part of Journal of Neuroinflammation, 2020.

DOI for Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson's disease brain Download full text (pdf) of Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson's disease brain

Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer

Ma, Jing; Ramachandran, Mohanraj; Jin, Chuan; Quijano-Rubio, Clara et al.

Part of Cell Death and Disease, 2020.

DOI for Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer Download full text (pdf) of Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer

TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment

Depreter, Barbara; Weening, Karin E.; Vandepoele, Karl; Essand, Magnus et al.

Part of Haematologica, p. 1306-1316, 2020.

DOI for TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment Download full text (pdf) of TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment

Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

Georganaki, Maria; Ramachandran, Mohanraj; Tuit, Sander; Nunez, Nicolas Gonzalo et al.

Part of Oncoimmunology, 2020.

DOI for Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy Download full text (pdf) of Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

Čančer, Matko; Hutter, Sonja; Holmberg Olausson, Karl; Rosén, Gabriela et al.

Part of Cell Stem Cell, p. 855-870, 2019.

DOI for Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy Download full text (pdf) of Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Xie, Yuan; Sundström, Anders; Maturi, Naga P; Tan, E-Jean et al.

Part of Journal of Pathology, p. 228-240, 2019.

DOI for LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Virus-Based Immunotherapy of Glioblastoma

Martikainen, Miika; Essand, Magnus

Part of Cancers, 2019.

DOI for Virus-Based Immunotherapy of Glioblastoma Download full text (pdf) of Virus-Based Immunotherapy of Glioblastoma

A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia

Enblad, Gunilla; Karlsson, Hannah; Gammelgård, Gustav; Wenthe, Jessica et al.

Part of Clinical Cancer Research, p. 6185-6194, 2018.

DOI for A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia

Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models

Fotaki, Grammatiki; Jin, Chuan; Kerzeli, Iliana Kyriaki; Ramachandran, Mohanraj et al.

Part of Oncoimmunology, 2018.

DOI for Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models Download full text (pdf) of Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models

CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis

Lugano, Roberta; Vemuri, Kalyani; Yu, Di; Bergqvist, Michael et al.

Part of Journal of Clinical Investigation, p. 3280-3297, 2018.

DOI for CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis Download full text (pdf) of CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis

Leukocyte differentiation by histidine-rich glycoprotein/stanniocalcin-2 complex regulates murine glioma growth through modulation of anti-tumor immunity

Roche, Francis P.; Pietilä, Ilkka; Kaito, Hiroshi; Sjöström, Elisabet O. et al.

Part of Molecular Cancer Therapeutics, p. 1961-1972, 2018.

DOI for Leukocyte differentiation by histidine-rich glycoprotein/stanniocalcin-2 complex regulates murine glioma growth through modulation of anti-tumor immunity Download full text (pdf) of Leukocyte differentiation by histidine-rich glycoprotein/stanniocalcin-2 complex regulates murine glioma growth through modulation of anti-tumor immunity

Modifying melanoma immune microenvironment by heterologous prime-boost vaccination with adenovirus and Modified Vaccinia Ankara virus vectors

Shridhar, N.; Ruotsalainen, J.; van der Sluis, T.; Rogava, M. et al.

Part of Experimental dermatology, p. E54-E55, 2018.

Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth

Younis, Shady; Kamel, Wael; Falkeborn, Tina; Wang, Hao et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. E3808-E3816, 2018.

DOI for Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth

Perivascular macrophages regulate blood flow following tissue damage

Vågesjö, Evelina; Seignez, Cedric; Christoffersson, Gustaf; Herrera Hidalgo, Carmen et al.

Part of European Journal of Clinical Investigation, p. 44-45, 2018.

DOI for Perivascular macrophages regulate blood flow following tissue damage

Pro-inflammatory allogeneic DCs promote activation of bystander immune cells and thereby license antigen-specific T-cell responses

Fotaki, Grammatiki; Jin, Chuan; Ramachandran, Mohanraj; Kerzeli, Iliana Kyriaki et al.

Part of Oncoimmunology, 2018.

DOI for Pro-inflammatory allogeneic DCs promote activation of bystander immune cells and thereby license antigen-specific T-cell responses

Adenovirus, Semliki Forest virus and vaccinia virus-induced immunogenic cell death augments oncolytic virus immunotherapy

Ma, Jing; Ramachandran, Mohanraj; Jin, Chuan; Essand, Magnus et al.

Part of Scandinavian Journal of Immunology, p. 341-341, 2017.

CAR T-Cells with Induced Secretion of Helicobacter Pylori Neutrophil-Activating Protein (HP-NAP) Yields Improved Anti-Tumor Activity and Reduced Immunosuppression

Essand, Magnus; Ma, Jing; Jin, Chuan; Ramachandran, Mohanraj et al.

Part of Molecular Therapy, p. 288-288, 2017.

Immunological biomarkers correlate to survival in CAR19-treated patients

Lövgren, Tanja; Wenthe, Jessica; Karlsson, S. C. Hannah; Gammelgård, Gustav et al.

Part of Scandinavian Journal of Immunology, p. 337-337, 2017.

Oncolytic alphavirus SFV-VA7 efficiently eradicates subcutaneous and orthotopic human prostate tumours in mice

Martikainen, Miika; Ruotsalainen, Janne; Tuomela, Johanna; Harkonen, Pirkko et al.

Part of British Journal of Cancer, p. 51-55, 2017.

DOI for Oncolytic alphavirus SFV-VA7 efficiently eradicates subcutaneous and orthotopic human prostate tumours in mice

PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c

Pan, Gang; Ameur, Adam; Enroth, Stefan; Bysani, Madhusudhan et al.

Part of Nucleic Acids Research, p. 2408-2422, 2017.

DOI for PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c

Preclinical Evaluation of AdVince, an Oncolytic Adenovirus Adapted for Treatment of Liver Metastases from Neuroendocrine Cancer

Yu, Di; Leja, Justyna; Loskog, Angelica S.; Hellman, Per et al.

Part of Neuroendocrinology, p. 54-66, 2017.

DOI for Preclinical Evaluation of AdVince, an Oncolytic Adenovirus Adapted for Treatment of Liver Metastases from Neuroendocrine Cancer

Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically administered triple microRNA-detargeted oncolytic Semliki Forest virus

Ramachandran, Mohanraj; Yu, Di; Dyczynski, Matheus; Baskaran, Sathishkumar et al.

Part of Clinical Cancer Research, p. 1519-1530, 2017.

DOI for Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically administered triple microRNA-detargeted oncolytic Semliki Forest virus

The cancer-immunity cycle as rational design for synthetic cancer drugs: Novel DC vaccines and CAR T-cells

Ramachandran, Mohanraj; Dimberg, Anna; Essand, Magnus

Part of Seminars in Cancer Biology, p. 23-35, 2017.

DOI for The cancer-immunity cycle as rational design for synthetic cancer drugs: Novel DC vaccines and CAR T-cells Download full text (pdf) of The cancer-immunity cycle as rational design for synthetic cancer drugs: Novel DC vaccines and CAR T-cells

A Clinical Trial Using Third Generation CD19 Targeting CAR T Cells for Relapsed Lymphoma and Leukemia

Enblad, Gunilla; Karlsson, Hannah; Wenthe, Jessica; Wikström, Kristina I. et al.

Part of Molecular Therapy, p. S295-S296, 2016.

Allogeneic dendritic cells (AlloDCs) transduced with an infection enhanced adenovirus as adjuvant for cancer immunotherapy

Fotaki, Grammatiki; Jin, Chuan; Karlsson-Parra, Alex; Yu, Di et al.

Part of CANCER IMMUNOLOGY RESEARCH, 2016.

DOI for Allogeneic dendritic cells (AlloDCs) transduced with an infection enhanced adenovirus as adjuvant for cancer immunotherapy

Avidity characterization of genetically engineered T-cells with novel and established approaches

Hillerdal, Victoria; Boura, Vanessa F.; Björkelund, Hanna; Andersson, Karl et al.

Part of BMC Immunology, 2016.

DOI for Avidity characterization of genetically engineered T-cells with novel and established approaches Download full text (pdf) of Avidity characterization of genetically engineered T-cells with novel and established approaches

CD19-targeting third generation CAR T cells for relapsed and refractory lymphoma and leukemia: report from the Swedish phase Ulla trial

Enblad, Gunilla; Karlsson, Hannah; Wikström, Kristina I.; Essand, Magnus et al.

Part of CANCER IMMUNOLOGY RESEARCH, 2016.

DOI for CD19-targeting third generation CAR T cells for relapsed and refractory lymphoma and leukemia: report from the Swedish phase Ulla trial

HAdV-2-suppressed growth of SV40 T antigen-transformed mouse mammary epithelial cell-induced tumours in SCID mice

Wu, Chengjun; Cao, Xiaofang; Yu, Di; Huijbers, Elisabeth J. M. et al.

Part of Virology, p. 44-50, 2016.

DOI for HAdV-2-suppressed growth of SV40 T antigen-transformed mouse mammary epithelial cell-induced tumours in SCID mice

Heparanase Promotes Glioma Progression and is Inversely Correlated with Patient Survival.

Kundu, Soumi; Xiong, Anqi; Spyrou, Argyris; Wicher, Grzegorz et al.

Part of Molecular Cancer Research, p. 1243-1253, 2016.

DOI for Heparanase Promotes Glioma Progression and is Inversely Correlated with Patient Survival.

Long-term episomal gene transfer for safe engineering of T cells for adoptive cell therapy of cancer

Jin, Chuan; Ramachandran, Mohanraj; Fotaki, Grammatiki; Nilsson, Berith et al.

Part of CANCER IMMUNOLOGY RESEARCH, 2016.

DOI for Long-term episomal gene transfer for safe engineering of T cells for adoptive cell therapy of cancer

miR-196a Is Specifically Regulated in FDG-PET Positive and Negative Small Intestinal Neuroendocrine Tumor Patients at Late Stage of Disease

Giandomenico, V; Li, Su-Chen; Lind, Thomas; Boccherini, M. et al.

Part of Neuroendocrinology, p. 115-115, 2016.

Prospects to improve chimeric antigen receptor T-cell therapy for solid tumors

Jin, Chuan; Yu, Di; Essand, Magnus

Part of Immunotherapy, p. 1355-1361, 2016.

DOI for Prospects to improve chimeric antigen receptor T-cell therapy for solid tumors

Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer

Jin, Chuan; Fotaki, Grammatiki; Ramachandran, Mohanraj; Nilsson, Berith et al.

Part of EMBO Molecular Medicine, p. 702-711, 2016.

DOI for Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer Download full text (pdf) of Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer

Chimeric Antigen Receptor-Engineered T Cells for the Treatment of Metastatic Prostate Cancer

Hillerdal, Victoria; Essand, Magnus

Part of BioDrugs, p. 75-89, 2015.

DOI for Chimeric Antigen Receptor-Engineered T Cells for the Treatment of Metastatic Prostate Cancer Download full text (pdf) of Chimeric Antigen Receptor-Engineered T Cells for the Treatment of Metastatic Prostate Cancer

Elevated Expression of the C-Type Lectin CD93 in the Glioblastoma Vasculature Regulates Cytoskeletal Rearrangements That Enhance Vessel Function and Reduce Host Survival

Langenkamp, Elise; Zhang, Lei; Lugano, Roberta; Huang, Hua et al.

Part of Cancer Research, p. 4504-4516, 2015.

DOI for Elevated Expression of the C-Type Lectin CD93 in the Glioblastoma Vasculature Regulates Cytoskeletal Rearrangements That Enhance Vessel Function and Reduce Host Survival

Immunological shielding by induced recruitment of regulatory T lymphocytes delays rejection of islets transplanted to muscle

Vågesjö, Evelina; Christoffersson, Gustaf; Waldén, Tomas B; Carlsson, Per-Ola et al.

Part of Cell Transplantation, p. 263-276, 2015.

DOI for Immunological shielding by induced recruitment of regulatory T lymphocytes delays rejection of islets transplanted to muscle

Immunological Shielding by Induced Recruitment of Regulatory T-Lymphocytes Delays Rejection of Islets Transplanted in Muscle

Vågesjö, Evelina; Christoffersson, Gustaf; Waldén, Tomas B; Carlsson, Per-Ola et al.

Part of Cell Transplantation, p. 263-276, 2015.

DOI for Immunological Shielding by Induced Recruitment of Regulatory T-Lymphocytes Delays Rejection of Islets Transplanted in Muscle

Mesenchymal stromal cells supportendothelial cell interactions in anintramuscular islet transplantation model

Fransson, Moa; Brännström, Johan; Duprez, Ida; Essand, Magnus et al.

Part of Regenerative Medicine Research, 2015.

DOI for Mesenchymal stromal cells supportendothelial cell interactions in anintramuscular islet transplantation model Download full text (pdf) of Mesenchymal stromal cells supportendothelial cell interactions in anintramuscular islet transplantation model

Other Novel Therapies: Biomarkers, microRNAs and microRNA Inhibitors, DNA Methylation, Epigenetics, Immunotherapy and Virotherapy

Giandomenico, Valeria; Thirlwell, Chrissie; Essand, Magnus

Part of Neuroendocrine Tumors, p. 248-262, 2015.

DOI for Other Novel Therapies: Biomarkers, microRNAs and microRNA Inhibitors, DNA Methylation, Epigenetics, Immunotherapy and Virotherapy

Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.

Zhang, Lei; Kundu, Soumi; Feenstra, Tjerk; Li, Xiujuan et al.

Part of Science Signaling, 2015.

DOI for Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.

Third Generation CD19-CAR T Cells for Relapsed and Refractory Lymphoma and Leukemia Report from the Swedish Phase I/IIa Trial

Enblad, Gunilla; Karlsson, Hannah; Wikström, Kristina; Essand, Magnus et al.

Part of Blood, 2015.

A Hexon and Fiber-modified Adenovirus Expressing CD40L Improves the Antigen Presentation Capacity of Dendritic Cells

Liljenfeldt, Lina; Yu, Di; Chen, Liye; Essand, Magnus et al.

Part of Journal of immunotherapy (1997), p. 155-162, 2014.

DOI for A Hexon and Fiber-modified Adenovirus Expressing CD40L Improves the Antigen Presentation Capacity of Dendritic Cells

Adenovirus Encoded Helicobacter pylori Neutrophil Activating Protein Promotes Maturation of DCs with Th-1 Polarization, Improved Antigen Presentation and Migration

Ramachandran, Mohanraj; Jin, Chuan; Yu, Di; Eriksson, Fredrik et al.

Part of Molecular Therapy, p. S242-S243, 2014.

Allogeneic lymphocyte-licensed DCs expand T cells withimproved antitumor activity and resistance to oxidative stress andimmunosuppressive factors

Jin, Chuan; Yu, Di; Hillerdal, Victoria; Wallgren, AnnaCarin et al.

Part of Molecular Therapy Methods & Clinical Development, 2014.

DOI for Allogeneic lymphocyte-licensed DCs expand T cells withimproved antitumor activity and resistance to oxidative stress andimmunosuppressive factors

Allogeneic Lymphocyte-Licensed DCs Expand TCR/CAR-Engineered T Cells, Which Are Insensitive To Oxidative Stress and Immunosuppressive Factors

Jin, Chuan; Yu, Di; Karlsson-Parra, Alex; Essand, Magnus

Part of Molecular Therapy, p. S62-S62, 2014.

Engineering Regulatory Cells With a T Cell Receptor for Controlled Activation

Hillerdal, Victoria; Berglund, David; Boura, Vanessa; Jin, Chuan et al.

Part of Molecular Therapy, p. S180-S180, 2014.

Histidine-Rich Glycoprotein (HRG): A Novel Gene-Therapy Effector for the Treatment of Cancer

Roche, Francis P.; Ohlin, Elisabet K.; Essand, Magnus; Claesson-Welsh, Lena

Part of Molecular Therapy, p. S243-S244, 2014.

Long-term episomal gene transfer for safe engineering of T-cells for adoptive cell therapy of cancer

Jin, Chuan; Ramachandran, Mohanraj; Fotaki, Grammatiki; Nilsson, Bo et al.

Part of Human Gene Therapy, p. A50-A50, 2014.

Preclinical Safety Assessment of Ad[I/PPT-E1A], a Novel Oncolytic Adenovirus for Prostate Cancer

Schenk, Ellen; Essand, Magnus; Kraaij, Robert; Adamson, Rachel et al.

Part of Human Gene Therapy Clinical Development, p. 7-15, 2014.

DOI for Preclinical Safety Assessment of Ad[I/PPT-E1A], a Novel Oncolytic Adenovirus for Prostate Cancer

Strategical steering of the immune system: induction of leukocyte vascular chaperoning increases functional blood flow responses in ischemic muscle

Vågesjö, Evelina; Christoffersson, Gustaf; Korsgren, Olle; Essand, Magnus et al.

Part of The FASEB Journal, 2014.

Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice

Hillerdal, Victoria; Ramachandran, Mohanraj; Leja, Justyna; Essand, Magnus

Part of BMC Cancer, p. 30-, 2014.

DOI for Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice Download full text (pdf) of Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice

Vector-Encoded Helicobacter pylori Neutrophil-Activating Protein Promotes Maturation of Dendritic Cells with Th1 Polarization and Improved Migration

Ramachandran, Mohanraj; Jin, Chuan; Yu, Di; Eriksson, Fredrik et al.

Part of Journal of Immunology, p. 2287-2296, 2014.

DOI for Vector-Encoded Helicobacter pylori Neutrophil-Activating Protein Promotes Maturation of Dendritic Cells with Th1 Polarization and Improved Migration

Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

Yu, Di; Jin, Chuan; Ramachandran, Mohanraj; Xu, Jing et al.

Part of PLOS ONE, p. e54952-, 2013.

DOI for Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures Download full text (pdf) of Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

An infection-enhanced oncolytic adenovirus secreting H. pylori neutrophil-activating protein with therapeutic effects on neuroendocrine tumors

Ramachandran, Mohanraj; Yu, Di; Wanders, Alkwin; Essand, Magnus et al.

Part of Molecular Therapy, p. 2008-2018, 2013.

DOI for An infection-enhanced oncolytic adenovirus secreting H. pylori neutrophil-activating protein with therapeutic effects on neuroendocrine tumors Download full text (pdf) of An infection-enhanced oncolytic adenovirus secreting H. pylori neutrophil-activating protein with therapeutic effects on neuroendocrine tumors

Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy

Karlsson, S. C. Hannah; Lindqvist, A. C.; Fransson, Moa; Paul-Wetterberg, Gabriella et al.

Part of Cancer Gene Therapy, p. 386-393, 2013.

DOI for Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy

Genetically engineered T cells for the treatment of cancer

Essand, Magnus; Loskog, Angelica S I

Part of Journal of Internal Medicine, p. 166-181, 2013.

DOI for Genetically engineered T cells for the treatment of cancer

Histidine-Rich Glycoprotein (HRG): A Novel Gene-Therapy Effector for the Treatment of Cancer

Roche, Francis P.; Ohlin, Elisabet; Essand, Magnus; Claesson-Welsh, Lena

Part of Molecular Therapy, p. S241-S241, 2013.

Islet Engraftment and Revascularization in Clinical and Experimental Transplantation

Molnár, Christian; Essand, Magnus; Wennberg, Lars; Berne, Christian et al.

Part of Cell Transplantation, p. 243-251, 2013.

DOI for Islet Engraftment and Revascularization in Clinical and Experimental Transplantation

Macrophage delivery of an oncolytic virus abolishes tumor regrowth and metastasis after chemotherapy or irradiation

Muthana, M.; Rodrigues, S.; Chen, Y. -Y; Welford, A. et al.

Part of Cancer Research, p. 490-495, 2013.

DOI for Macrophage delivery of an oncolytic virus abolishes tumor regrowth and metastasis after chemotherapy or irradiation

Strategic recruitment of proangiogenic leukocytes to the ischemic hindlimb increases functional tissue perfusion

Vågesjö, Evalina; Christoffersson, Gustaf; Korsgren, Olle; Essand, Magnus et al.

Part of European Journal of Clinical Investigation, p. 27-27, 2013.

Tat‐PTD‐modified Oncolytic Adenovirus Driven by the SCG3 Promoter and ASH1 Enhancer for Neuroblastoma Therapy

Jin, Chuan; Yu, Di; Čančer, Matko; Nilsson, Berith et al.

Part of Human Gene Therapy, p. 766-775, 2013.

DOI for Tat‐PTD‐modified Oncolytic Adenovirus Driven by the SCG3 Promoter and ASH1 Enhancer for Neuroblastoma Therapy Download full text (pdf) of Tat‐PTD‐modified Oncolytic Adenovirus Driven by the SCG3 Promoter and ASH1 Enhancer for Neuroblastoma Therapy

Virotherapy of Neuroendocrine Tumors

Essand, Magnus

Part of Neuroendocrinology, p. 26-34, 2013.

DOI for Virotherapy of Neuroendocrine Tumors

Age-related somatic structural changes in the nuclear genome of human blood cells

Forsberg, Lars A.; Rasi, Chiara; Razzaghian, Hamid R; Pakalapati, Geeta et al.

Part of American Journal of Human Genetics, p. 217-228, 2012.

DOI for Age-related somatic structural changes in the nuclear genome of human blood cells

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

Fransson, Moa; Piras, Elena; Burman, Joachim; Nilsson, Berith et al.

Part of Journal of Neuroinflammation, p. 112-, 2012.

DOI for CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery Download full text (pdf) of CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

In Vitro Primary Cell Culture as a Physiologically Relevant Method for Preclinical Testing of Human Oncolytic Adenovirus

Adamson, R. E.; Frazier, A. A.; Evans, H.; Chambers, K. F. et al.

Part of Human Gene Therapy, p. 218-230, 2012.

DOI for In Vitro Primary Cell Culture as a Physiologically Relevant Method for Preclinical Testing of Human Oncolytic Adenovirus

T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2⁺ prostate and breast cancer cells

Hillerdal, Victoria; Nilsson, Berith; Carlsson, Björn; Eriksson, Fredrik et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 15877-15881, 2012.

DOI for T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2⁺ prostate and breast cancer cells

Adenovirus with Hexon Tat-Protein Transduction Domain Modification Exhibits Increased Therapeutic Effect in Experimental Neuroblastoma and Neuroendocrine Tumors

Yu, Di; Jin, Chuan; Leja, Justyna; Majdalani, Nadim et al.

Part of Journal of Virology, p. 13114-13123, 2011.

DOI for Adenovirus with Hexon Tat-Protein Transduction Domain Modification Exhibits Increased Therapeutic Effect in Experimental Neuroblastoma and Neuroendocrine Tumors Download full text (pdf) of Adenovirus with Hexon Tat-Protein Transduction Domain Modification Exhibits Increased Therapeutic Effect in Experimental Neuroblastoma and Neuroendocrine Tumors

Oncolytic adenovirus modified with somatostatin motifs for selective infection of neuroendocrine tumor cells

Leja, Justyna; Yu, Di; Nilsson, Berith; Gedda, Lars et al.

Part of Gene Therapy, p. 1052-1062, 2011.

DOI for Oncolytic adenovirus modified with somatostatin motifs for selective infection of neuroendocrine tumor cells

Oncolytic Viruses for the Treatment of Neuroendocrine Tumors

Essand, Magnus; Leja, Justyna; Giandomenico, Valeria; Öberg, Kjell E.

Part of Hormone and Metabolic Research, p. 877-883, 2011.

DOI for Oncolytic Viruses for the Treatment of Neuroendocrine Tumors

The HDAC Inhibitor FK228 Enhances Adenoviral Transgene Expression by a Transduction-Independent Mechanism but Does Not Increase Adenovirus Replication

Danielsson, Angelika; Dzojic, Helena; Rashkova, Victoria; Cheng, Wing-Shing et al.

Part of PLoS ONE, p. e14700-, 2011.

DOI for The HDAC Inhibitor FK228 Enhances Adenoviral Transgene Expression by a Transduction-Independent Mechanism but Does Not Increase Adenovirus Replication

Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Muthana, Munitta; Giannoudis, Athina; Scott, Simon D.; Fang, Hsin-Yu et al.

Part of Cancer Research, p. 1805-1815, 2011.

DOI for Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood

Danielsson, Angelika; Elgue, Graciela; Nilsson, Berith M.; Nilsson, Bo et al.

Part of Gene Therapy, p. 752-762, 2010.

DOI for An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood

Clinical Adenoviral Gene Therapy for Prostate Cancer

Schenk, Ellen; Essand, Magnus; Bangma, Chris

Part of Human Gene Therapy, p. 807-813, 2010.

DOI for Clinical Adenoviral Gene Therapy for Prostate Cancer

Double-detargeted oncolytic adenovirus shows replication arrest in liver cells and retains neuroendocrine cell killing ability

Leja, Justyna; Nilsson, Berith; Yu, Di; Gustafson, Elisabet et al.

Part of PLOS ONE, p. e8916-, 2010.

DOI for Double-detargeted oncolytic adenovirus shows replication arrest in liver cells and retains neuroendocrine cell killing ability

Gene Transfer Vectors Targeted to Human Prostate Cancer: Do We Need Better Preclinical Testing Systems?

Maitland, Norman; Chambers, Karen; Georgopoulos, Lindsay; Simpson-Holley, Martha et al.

Part of Human Gene Therapy, p. 815-827, 2010.

DOI for Gene Transfer Vectors Targeted to Human Prostate Cancer: Do We Need Better Preclinical Testing Systems?

Generation of antigen-specific cytolytic T cells for prostate cancer therapy

Rashkova, Victoria; Essand, Magnus

Part of Human Gene Therapy, p. 1422-1422, 2010.

High frequency of prostate antigen-directed T cells in cancer patients compared to healthy age-matched individuals

Forsberg, Ole; Carlsson, Björn; Malmström, Per-Uno; Ullenhag, Gustav et al.

Part of The Prostate, p. 70-81, 2009.

DOI for High frequency of prostate antigen-directed T cells in cancer patients compared to healthy age-matched individuals Download full text (pdf) of High frequency of prostate antigen-directed T cells in cancer patients compared to healthy age-matched individuals

Midgut carcinoid patients display increased numbers of regulatory T cells in peripheral blood with infiltration into tumor tissue

Vikman, Sofia; Sommaggio, Roberta; De La Torre, Manuel; Öberg, Kjell et al.

Part of Acta Oncologica, p. 391-400, 2009.

DOI for Midgut carcinoid patients display increased numbers of regulatory T cells in peripheral blood with infiltration into tumor tissue Download full text (pdf) of Midgut carcinoid patients display increased numbers of regulatory T cells in peripheral blood with infiltration into tumor tissue

Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas

Leja, Justyna; Essaghir, Ahmed; Essand, Magnus; Wester, Kenneth et al.

Part of Modern Pathology, p. 261-272, 2009.

DOI for Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas

CD8(+) T cells against multiple tumor-associated antigens in peripheral blood of midgut carcinoid patients

Vikman, Sofia; Giandomenico, Valeria; Sommaggio, Roberta; Öberg, Kjell et al.

Part of Cancer Immunology and Immunotherapy, p. 399-409, 2008.

DOI for CD8(+) T cells against multiple tumor-associated antigens in peripheral blood of midgut carcinoid patients

CpG oligonucleotides demonstrate increased therapeutic efficacy compared to BCG in an aggressive orthotopic bladder cancer model

Ninalga, Christina; Mangsbo, Sara; Loskog, Angelica; Essand, Magnus et al.

Part of Journal of immunotherapy (1997), p. 34-42, 2008.

DOI for CpG oligonucleotides demonstrate increased therapeutic efficacy compared to BCG in an aggressive orthotopic bladder cancer model

CpG Therapy is Superior to BCG in an Orthotopic Bladder Cancer Model and Generates CD4+ T-cell Immunity

Mangsbo, Sara M; Ninalga, Christina; Essand, Magnus; Loskog, Angelica et al.

Part of Journal of immunotherapy (1997), p. 34-42, 2008.

DOI for CpG Therapy is Superior to BCG in an Orthotopic Bladder Cancer Model and Generates CD4+ T-cell Immunity

Increased therapeutic efficacy of the prostate-specific oncolytic adenovirus Ad[I/PPT-E1A] by reduction of the insulator size and introduction of the full-length E3 region

Danielsson, Angelika; Dzojic, H; Nilsson, B; Essand, M

Part of Cancer Gene Therapy, p. 203-213, 2008.

DOI for Increased therapeutic efficacy of the prostate-specific oncolytic adenovirus Ad[I/PPT-E1A] by reduction of the insulator size and introduction of the full-length E3 region

Strategic use of an adenoviral vector for rapid and efficient ex vivo-generation of cytomegalovirus pp65-reactive cytolytic and helper T cells

Forsberg, Ole; Carlsson, Björn; Tötterman, Thomas H.; Essand, Magnus

Part of British Journal of Haematology, p. 188-199, 2008.

DOI for Strategic use of an adenoviral vector for rapid and efficient ex vivo-generation of cytomegalovirus pp65-reactive cytolytic and helper T cells Download full text (pdf) of Strategic use of an adenoviral vector for rapid and efficient ex vivo-generation of cytomegalovirus pp65-reactive cytolytic and helper T cells