Clinical, epidemiological and tumour biology studies of different cancer forms
Our research focuses on clinically important questions in several cancer forms. Our studies are based on our knowledge from the clinic and takes advantage of the many national and local registries in Sweden.
Hodgkin lymphoma affects young adults and is today a curable disease with intensive chemotherapy. We have since many years studied cancer survivorship in Hodgkin lymphoma patients and we have been able to evaluate very long-term effects and side effects of oncological therapies.
We have a close collaboration with the epidemiology group at Karolinska Institutet. In addition, we have an extensive ongoing collaboration with the Pathology department, IGP, where we study the tumour microenvironment in Hodgkin lymphoma, and with the Lymphoma group in Uppsala, chaired by Gunilla Enblad.
Mantle cell lymphoma
Mantle cell lymphoma is currently one of the lymphomas with poorest long-term survival and novel treatment concepts are urgently needed. However, in addition to the short expected survival there are also other challenges such as an ageing population, many new drugs and difficulties knowing for which patient groups new drugs should be introduced.
By active participation in the Nordic Mantle Cell lymphoma group, we have been involved in introducing and evaluating several new targeted drugs for mantle cell lymphoma In a randomized phase III trial in elderly patients, we are testing whether a chemotherapy free concept can improve survival (the ENRICH trial).
Currently, we are studying the impact of associated diseases on the prognosis of mantle cell lymphoma. In addition, we investigate the tumour microenvironment in mantle cell lymphoma, with the aim to identify new prognostic and predictive markers.
Pregnancy and the risk of cancer
Another research focus in the group is perinatal risk factors, pregnancy and the risk of cancer. Our studies on the association between pregnancies and later cancer risk in the mother have recently been published in two original papers and a review article.
In the first article we show that a full-length pregnancy protects against epithelial ovarian cancer to a higher extent than a pregnancy resulting in preterm delivery. In the second article, we show a decreased risk of breast cancer for females experiencing high blood pressure prior to and during pregnancy. In the review we both illustrate and discuss different aspects of pregnancy and a later risk of several solid malignancies.
We also study solid cancers, particularly studies on ovarian cancer and cervical cancer. Moreover, we have ongoing studies on testicular cancer and are at present investigating, in particular, the risk associated with psychiatric comorbidity and testicular cancer.