Tobias Sjöblom – Finding and understanding cancer-causing mutations
Our research focuses on molecular changes in cancer and is centred on four main topics:
Identification of cancer-causing mutations.
Investigation of how specific mutations contribute to tumour development or metastasis.
Strategies to utilize specific genetic properties of cancer cells for targeted anti-cancer treatment.
Development of methods and procedures to aid or improve diagnosis.
We utilise molecular biology, databases and clinical data as well as patient material, cell lines and other tumour models to learn more about cancer development and how to detect and combat tumours effectively. Most of our work concerns colorectal cancer but in some projects we also study other types of cancer. Ongoing research includes e.g. identification and functional studies of genetic aberrations in colorectal cancers, development of a novel cancer treatment and identification of biomarkers to enable blood-based cancer diagnostics tests.
Our research has previously resulted in spin-out companies to enable implementation of research results in health care. Oncodia AB develops CE/IVD approved software and reagent kits for application in clinical genomics that guides treatment selection.
Translational cancer research is dependent on high quality patient materials and Tobias Sjöblom is Director of the U-CAN project, where clinical samples and information are collected from cancer patients for the purpose of supporting high quality research. He also heads the research infrastructure of Biobank Sweden.