Jan Dumanski – Molecular oncology

Analysis of post-zygotic or somatic genetic variation (somatic mosaicism) is the overall theme of research in the group. We work with translational disease-related projects and with basic questions addressing somatic variation in normal human cells. An emphasis is on structural genetic variation, which has emerged over the past 10 years as a dominating type of human inter-individual variation.

Our specific projects are:

Mosaic loss of chromosome Y (LOY) in blood cells is associated with smoking as well as shorter survival and higher risk of cancer in men
Post-zygotic genetic variation: studies of human aging/longevity and age-associated aberrations
Novel bio-markers for breast cancer; disease prediction and progression