Publications in DiVA – Claes Wadelius

Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment

Garbulowski, Mateusz; Smolinska Garbulowska, Karolina; Cabuk, Ugur; Younes, Sara et al.

Part of Cancers, 2022.

DOI for Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment Download full text (pdf) of Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment

Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues

Diamanti, Klev; Cavalli, Marco; Pereira, Maria J.; Pan, Gang et al.

Part of Cell Reports Medicine, 2022.

DOI for Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues Download full text (pdf) of Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues

scSPLAT, a scalable plate-based protocol for single cell WGBS library preparation

Raine, Amanda; Lundmark, Anders; Annett, Alva; Wiman, Ann-Christin et al.

Part of Scientific Reports, 2022.

DOI for scSPLAT, a scalable plate-based protocol for single cell WGBS library preparation Download full text (pdf) of scSPLAT, a scalable plate-based protocol for single cell WGBS library preparation

Functional annotation of noncoding mutations in cancer

Umer, Husen Muhammad; Smolinska, Karolina; Komorowski, Jan; Wadelius, Claes

Part of Life Science Alliance, 2021.

DOI for Functional annotation of noncoding mutations in cancer Download full text (pdf) of Functional annotation of noncoding mutations in cancer

Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate

Karlsson Sundbaum, Johanna; Baecklund, Eva; Eriksson, Niclas; Kohnke, Hugo et al.

Part of Pharmacogenomics (London), p. 973-982, 2021.

DOI for Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate Download full text (pdf) of Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate

Multifaceted regulation of hepatic lipid metabolism by YY1

Pan, Gang; Diamanti, Klev; Cavalli, Marco; Gutierrez, Ariadna Lara et al.

Part of Life Science Alliance, 2021.

DOI for Multifaceted regulation of hepatic lipid metabolism by YY1 Download full text (pdf) of Multifaceted regulation of hepatic lipid metabolism by YY1

Polymorphisms rs55710213 and rs56334587 regulate SCD1 expression by modulating HNF4A binding

Pan, Gang; Cavalli, Marco; Wadelius, Claes

Part of Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, 2021.

DOI for Polymorphisms rs55710213 and rs56334587 regulate SCD1 expression by modulating HNF4A binding Download full text (pdf) of Polymorphisms rs55710213 and rs56334587 regulate SCD1 expression by modulating HNF4A binding

Single nucleus transcriptomics data integration recapitulates the major cell types in human liver

Diamanti, Klev; Inda Díaz, Juan Salvador; Raine, Amanda; Pan, Gang et al.

Part of Hepatology Research, p. 233-238, 2021.

DOI for Single nucleus transcriptomics data integration recapitulates the major cell types in human liver Download full text (pdf) of Single nucleus transcriptomics data integration recapitulates the major cell types in human liver

The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver

Cavalli, Marco; Diamanti, Klev; Dang, Yonglong; Xing, Pengwei et al.

Part of Omics, p. 652-659, 2021.

DOI for The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver Download full text (pdf) of The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver

A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human Liver

Cavalli, Marco; Diamanti, Klev; Pan, Gang; Spalinskas, Rapolas et al.

Part of Omics, p. 180-194, 2020.

DOI for A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human Liver Download full text (pdf) of A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human Liver

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Rheinbay, Esther; Nielsen, Morten Muhlig; Abascal, Federico; Wala, Jeremiah A. et al.

Part of Nature, p. 102-111, 2020.

DOI for Analyses of non-coding somatic drivers in 2,658 cancer whole genomes Download full text (pdf) of Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis

Carlevaro-Fita, Joana; Lanzos, Andres; Feuerbach, Lars; Hong, Chen et al.

Part of Communications Biology, 2020.

DOI for Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis Download full text (pdf) of Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis

Combined burden and functional impact tests for cancer driver discovery using DriverPower

Shuai, Shimin; Gallinger, Steven; Stein, Lincoln

Part of Nature Communications, 2020.

DOI for Combined burden and functional impact tests for cancer driver discovery using DriverPower Download full text (pdf) of Combined burden and functional impact tests for cancer driver discovery using DriverPower

Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment.

Rasmussen, Eva Rye; Hallberg, Pär; Baranova, Ekaterina V; Eriksson, Niclas et al.

Part of The Pharmacogenomics Journal, p. 770-783, 2020.

DOI for Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment. Download full text (pdf) of Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment.

Integration of whole-body [¹⁸F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes

Diamanti, Klev; Visvanathar, Robin; Pereira, Maria J.; Cavalli, Marco et al.

Part of Scientific Reports, 2020.

DOI for Integration of whole-body [¹⁸F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes Download full text (pdf) of Integration of whole-body [¹⁸F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes

Integrative pathway enrichment analysis of multivariate omics data.

Paczkowska, Marta; Barenboim, Jonathan; Sintupisut, Nardnisa; Fox, Natalie S et al.

Part of Nature Communications, 2020.

DOI for Integrative pathway enrichment analysis of multivariate omics data.

Pan-cancer analysis of whole genomes

Campbell, Peter J.; Diamanti, Klev; Komorowski, Jan; Umer, Husen Muhammad et al.

Part of Nature, p. 82-93, 2020.

DOI for Pan-cancer analysis of whole genomes Download full text (pdf) of Pan-cancer analysis of whole genomes

Pathway and network analysis of more than 2500 whole cancer genomes.

Reyna, Matthew A; Haan, David; Paczkowska, Marta; Verbeke, Lieven P C et al.

Part of Nature Communications, 2020.

DOI for Pathway and network analysis of more than 2500 whole cancer genomes. Download full text (pdf) of Pathway and network analysis of more than 2500 whole cancer genomes.

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.

Bailey, Matthew H; Meyerson, William U; Dursi, Lewis Jonathan; Wang, Liang-Bo et al.

Part of Nature Communications, 2020.

DOI for Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Download full text (pdf) of Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.

rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression

Pan, Gang; Cavalli, Marco; Carlsson, Björn; Skrtic, Stanko et al.

Part of iScience, 2020.

DOI for rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression Download full text (pdf) of rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression

Sex differences in oncogenic mutational processes.

Li, Constance H; Prokopec, Stephenie D; Sun, Ren X; Yousif, Fouad et al.

Part of Nature Communications, 2020.

DOI for Sex differences in oncogenic mutational processes.

Allele specific chromatin signals, 3D interactions, and motif predictions for immune and B cell related diseases

Cavalli, Marco; Baltzer, Nicholas; Umer, Husen Muhammad; Grau, Jan et al.

Part of Scientific Reports, 2019.

DOI for Allele specific chromatin signals, 3D interactions, and motif predictions for immune and B cell related diseases Download full text (pdf) of Allele specific chromatin signals, 3D interactions, and motif predictions for immune and B cell related diseases

Contribution of genetics to visceral adiposity and its relation to cardiovascular and metabolic disease.

Karlsson, Torgny; Rask-Andersen, Mathias; Pan, Gang; Höglund, Julia et al.

Part of Nature Medicine, p. 1390-1395, 2019.

DOI for Contribution of genetics to visceral adiposity and its relation to cardiovascular and metabolic disease.

Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation

Castillejo-Lopez, Casimiro; Pjanic, Milos; Pirona, Anna Chiara; Hetty, Susanne et al.

Part of iScience, p. 42-59, 2019.

DOI for Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation Download full text (pdf) of Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation

Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes

Diamanti, Klev; Cavalli, Marco; Pan, Gang; Pereira, Maria J et al.

Part of Scientific Reports, 2019.

DOI for Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes Download full text (pdf) of Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes

Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival

Hallberg, Pär; Smedje, Hans; Eriksson, Niclas; Kohnke, Hugo et al.

Part of EBioMedicine, p. 595-604, 2019.

DOI for Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival Download full text (pdf) of Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival

Studies of liver tissue identify functional gene regulatory elements associated to gene expression, type 2 diabetes, and other metabolic diseases

Cavalli, Marco; Baltzer, Nicholas; Pan, Gang; Walls, Jose Ramon Barcenas et al.

Part of Human Genomics, 2019.

DOI for Studies of liver tissue identify functional gene regulatory elements associated to gene expression, type 2 diabetes, and other metabolic diseases Download full text (pdf) of Studies of liver tissue identify functional gene regulatory elements associated to gene expression, type 2 diabetes, and other metabolic diseases

Genetic prevention of hepatitis C virus-induced liver fibrosis by allele-specific downregulation of MERTK

Cavalli, Marco; Pan, Gang; Nord, Helena; Wallén Arzt, Emelie et al.

Part of Hepatology Research, p. 826-830, 2017.

DOI for Genetic prevention of hepatitis C virus-induced liver fibrosis by allele-specific downregulation of MERTK

Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population

Hallberg, Pär; Persson, Matilda; Axelsson, Tomas; Cavalli, Marco et al.

Part of Pharmacogenomics (London), p. 201-213, 2017.

DOI for Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population Download full text (pdf) of Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population

PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c

Pan, Gang; Ameur, Adam; Enroth, Stefan; Bysani, Madhusudhan et al.

Part of Nucleic Acids Research, p. 2408-2422, 2017.

DOI for PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c

A Significant Regulatory Mutation Burden at a High-Affinity Position of the CTCF Motif in Gastrointestinal Cancers

Umer, Husen M.; Cavalli, Marco; Dabrowski, Michal J.; Diamanti, Klev et al.

Part of Human Mutation, p. 904-913, 2016.

DOI for A Significant Regulatory Mutation Burden at a High-Affinity Position of the CTCF Motif in Gastrointestinal Cancers

Allele-specific transcription factor binding in liver and cervix cells unveils many likely drivers of GWAS signals

Cavalli, Marco; Pan, Gang; Nord, Helena; Arzt, Emelie Wallén et al.

Part of Genomics, p. 248-254, 2016.

DOI for Allele-specific transcription factor binding in liver and cervix cells unveils many likely drivers of GWAS signals Download full text (pdf) of Allele-specific transcription factor binding in liver and cervix cells unveils many likely drivers of GWAS signals

Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression

Cavalli, Marco; Pan, Gang; Nord, Helena; Wallerman, Ola et al.

Part of Human Genetics, p. 485-497, 2016.

DOI for Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression Download full text (pdf) of Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression

Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy

Eriksson, Niclas; Wallentin, Lars; Berglund, Lars; Axelsson, Tomas et al.

Part of Pharmacogenomics (London), p. 1425-1439, 2016.

DOI for Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy Download full text (pdf) of Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy

Looking beyond GWAS: allele-specific transcription factor binding drives the association of GALNT2 to HDL-C plasma levels

Cavalli, Marco; Pan, Gang; Nord, Helena; Wadelius, Claes

Part of Lipids in Health and Disease, 2016.

DOI for Looking beyond GWAS: allele-specific transcription factor binding drives the association of GALNT2 to HDL-C plasma levels Download full text (pdf) of Looking beyond GWAS: allele-specific transcription factor binding drives the association of GALNT2 to HDL-C plasma levels

Maps of context-dependent putative regulatory regions and genomic signal interactions

Diamanti, Klev; Umer, Husen M.; Kruczyk, Marcin; Dabrowski, Michal J. et al.

Part of Nucleic Acids Research, p. 9110-9120, 2016.

DOI for Maps of context-dependent putative regulatory regions and genomic signal interactions Download full text (pdf) of Maps of context-dependent putative regulatory regions and genomic signal interactions

Novel regulatory variant detected on the VKORC1 haplotype that is associated with warfarin dose

Cavalli, Marco; Pan, Gang; Nord, Helena; Eriksson, Niclas et al.

Part of Pharmacogenomics (London), p. 1305-1314, 2016.

DOI for Novel regulatory variant detected on the VKORC1 haplotype that is associated with warfarin dose Download full text (pdf) of Novel regulatory variant detected on the VKORC1 haplotype that is associated with warfarin dose

Different distribution of histone modifications in genes with unidirectional and bidirectional transcription and a role of CTCF and cohesin in directing transcription

Bornelöv, Susanne; Komorowski, Jan; Wadelius, Claes

Part of BMC Genomics, 2015.

DOI for Different distribution of histone modifications in genes with unidirectional and bidirectional transcription and a role of CTCF and cohesin in directing transcription Download full text (pdf) of Different distribution of histone modifications in genes with unidirectional and bidirectional transcription and a role of CTCF and cohesin in directing transcription

lobChIP: from cells to sequencing ready ChIP libraries in a single day

Wallerman, Ola; Nord, Helena; Bysani, Madhusudhan; Borghini, Lisa et al.

Part of Epigenetics & Chromatin, 2015.

DOI for lobChIP: from cells to sequencing ready ChIP libraries in a single day Download full text (pdf) of lobChIP: from cells to sequencing ready ChIP libraries in a single day

Best vitelliform macular dystrophy in a Swedish family: genetic analysis and a seven-year follow-up of photodynamic treatment of a young boy with choroidal neovascularization

Frennesson, Christina I.; Wadelius, Claes; Nilsson, Sven Erik G.

Part of Acta Ophthalmologica, p. 238-242, 2014.

DOI for Best vitelliform macular dystrophy in a Swedish family: genetic analysis and a seven-year follow-up of photodynamic treatment of a young boy with choroidal neovascularization

Integration of genome-wide of Stat3 binding and epigenetic modification mapping with transcriptome reveals novel Stat3 target genes in glioma cells

Kruczyk, Marcin; Przanowski, Piotr; Dabrowski, Michal; Swiatek-Machado, Karolina et al.

Part of Biochimica et Biophysica Acta, p. 1341-1350, 2014.

DOI for Integration of genome-wide of Stat3 binding and epigenetic modification mapping with transcriptome reveals novel Stat3 target genes in glioma cells

Nucleosome regulatory dynamics in response to TGF beta

Enroth, Stefan; Andersson, Robin; Bysani, Madhusudhan; Wallerman, Ola et al.

Part of Nucleic Acids Research, p. 6921-6934, 2014.

DOI for Nucleosome regulatory dynamics in response to TGF beta

Nucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells

Enroth, Stefan; Andersson, Robin; Bysani, Madhusudhan Reddy; Wallerman, Ola et al.

Part of Nucleic Acids Research, p. 6921-6934, 2014.

DOI for Nucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells

ChIP-seq in steatohepatitis and normal liver tissue identifies candidate disease mechanisms related to progression to cancer

Bysani, Madhu Sudhan Reddy; Wallerman, Ola; Bornelöv, Susanne; Zatloukal, Kurt et al.

Part of BMC Medical Genomics, p. 50-, 2013.

DOI for ChIP-seq in steatohepatitis and normal liver tissue identifies candidate disease mechanisms related to progression to cancer

Genetic Determinants of Dabigatran Plasma Levels and Their Relation to Bleeding

Paré, Guillaume; Eriksson, Niclas; Lehr, Thorsten; Connolly, Stuart et al.

Part of Circulation, p. 1404-, 2013.

DOI for Genetic Determinants of Dabigatran Plasma Levels and Their Relation to Bleeding

A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements

Enroth, Stefan; Andersson, Claes R.; Andersson, Robin; Wadelius, Claes et al.

Part of Algorithms for Molecular Biology, p. 2-, 2012.

DOI for A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements Download full text (pdf) of A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements

Combinations of histone modifications mark exon inclusion levels

Enroth, Stefan; Bornelöv, Susanne; Wadelius, Claes; Komorowski, Jan

Part of PLOS ONE, 2012.

DOI for Combinations of histone modifications mark exon inclusion levels Download full text (pdf) of Combinations of histone modifications mark exon inclusion levels

Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa

Enroth, Stefan; Rada-Iglesisas, Alvaro; Andersson, Robin; Wallerman, Ola et al.

Part of BMC Cancer, p. 450-, 2011.

DOI for Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa Download full text (pdf) of Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa

Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma

Thorleifsson, Gudmar; Walters, G. Bragi; Hewitt, Alex W.; Masson, Gisli et al.

Part of Nature Genetics, p. 906-909, 2010.

DOI for Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma

Integrative epigenomic and genomic analysis of malignant pheochromocytoma.

Sandgren, Johanna; Andersson, A; Rada-Iglesias, A; Enroth, S et al.

Part of Experimental and Molecular Medicine, p. 484-502, 2010.

Integrative epigenomic and genomic analysis of malignant pheochromocytoma

Sandgren, Johanna; Andersson, Robin; Rada-Iglesias, Alvaro; Enroth, Stefan et al.

Part of Experimental and Molecular Medicine, p. 484-502, 2010.

DOI for Integrative epigenomic and genomic analysis of malignant pheochromocytoma

SICTIN: Rapid footprinting of massively parallel sequencing data

Enroth, Stefan; Andersson, Robin; Wadelius, Claes; Komorowski, Jan

Part of BioData Mining, 2010.

DOI for SICTIN: Rapid footprinting of massively parallel sequencing data Download full text (pdf) of SICTIN: Rapid footprinting of massively parallel sequencing data

Two polypyrimidine tracts in the nitric oxide synthase 2 gene: similar regulatory sequences with different properties

Motallebipour, Mehdi; Rada-Iglesias, Alvaro; Westin, Gunnar; Wadelius, Claes

Part of Molecular Biology Reports, p. 2021-2030, 2010.

DOI for Two polypyrimidine tracts in the nitric oxide synthase 2 gene: similar regulatory sequences with different properties

Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq

Motallebipour, Mehdi; Ameur, Adam; Bysani, Madhusudhan Reddy; Patra, Kalicharan et al.

Part of Genome Biology, p. R129-, 2009.

DOI for Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq

Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation

Rada-Iglesias, Alvaro; Enroth, Stefan; Andersson, Robin; Wanders, Alkwin et al.

Part of Epigenetics, p. 107-113, 2009.

Identification of candidate regulatory SNPs by combination of transcription-factor-binding site prediction, SNP genotyping and haploChIP

Ameur, Adam; Rada-Iglesias, Alvaro; Komorowski, Jan; Wadelius, Claes

Part of Nucleic Acids Research, p. e85-, 2009.

DOI for Identification of candidate regulatory SNPs by combination of transcription-factor-binding site prediction, SNP genotyping and haploChIP

Integrating genome and epigenome in human disease

Wadelius, Claes

Part of Epigenomics, p. 343-368, 2009.

DOI for Integrating genome and epigenome in human disease

Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing

Wallerman, Ola; Motallebipour, Mehdi; Enroth, Stefan; Patra, Kalicharan et al.

Part of Nucleic Acids Research, p. 7498-7508, 2009.

DOI for Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing

Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing

Wallerman, Ola; Motallebipour, Mehdi; Enroth, Stefan; Patra, Kalicharan et al.

Part of Nucleic Acids Research, p. 7498-7508, 2009.

DOI for Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing

Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection

Motallebipour, Mehdi; Enroth, Stefan; Punga, Tanel; Ameur, Adam et al.

Part of The FEBS Journal, p. 1878-1890, 2009.

DOI for Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection

Nucleosomes are well positioned in exons and carry characteristic histone modifications

Andersson, Robin; Enroth, Stefan; Rada-Iglesias, Alvaro; Wadelius, Claes et al.

Part of Genome Research, p. 1732-1741, 2009.

DOI for Nucleosomes are well positioned in exons and carry characteristic histone modifications

Two polypyrimidine tracts in the nitric oxide synthase 2 gene: similar regulatory sequences with different properties.

Motallebipour, M; Rada-Iglesias, A; Westin, Gunnar; Wadelius, Claes

Part of Molecular Biology Reports, p. 2021-2030, 2009.

ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth

Markljung, Ellen; Jiang, Lin; Jaffe, Jacob D.; Mikkelsen, Tarjei S. et al.

Part of PLoS biology, p. e1000256-, 2009.

DOI for ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth

Influence of adenosine triphosphate and ABCB1 (MDR1) genotype on the P-glycoprotein-dependent transfer of saquinavir in the dually perfused human placenta

Rahi, M.; Heikkinen, T.; Hakkola, J.; Hakala, K. et al.

Part of Human and Experimental Toxicology, p. 65-71, 2008.

DOI for Influence of adenosine triphosphate and ABCB1 (MDR1) genotype on the P-glycoprotein-dependent transfer of saquinavir in the dually perfused human placenta

Monte Carlo feature selection for supervised classification

Draminski, Michal; Rada-Iglesias, Alvaro; Enroth, Stefan; Wadelius, Claes et al.

Part of Bioinformatics, p. 110-117, 2008.

DOI for Monte Carlo feature selection for supervised classification

ORegAnno: an open-access community-driven resource for regulatory annotation

Griffith, Obi L.; Montgomery, Stephen B.; Bernier, Bridget; Chu, Bryan et al.

Part of Nucleic Acids Research, p. D107-D113, 2008.

DOI for ORegAnno: an open-access community-driven resource for regulatory annotation

Whole-genome maps of USF1 and USF2 binding and histone H3 acetylation reveal new aspects of promoter structure and candidate genes for common human disorders

Rada-Iglesias, Alvaro; Ameur, Adam; Kapranov, Philipp; Enroth, Stefan et al.

Part of Genome Research, p. 380-392, 2008.

DOI for Whole-genome maps of USF1 and USF2 binding and histone H3 acetylation reveal new aspects of promoter structure and candidate genes for common human disorders

Association of warfarin dose with genes involved in its action and metabolism

Wadelius, Mia; Chen, Leslie Y.; Eriksson, Niclas; Bumpstead, Suzannah et al.

Part of Human Genetics, p. 23-34, 2007.

DOI for Association of warfarin dose with genes involved in its action and metabolism

Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes

Rada-Iglesias, Alvaro; Enroth, Stefan; Ameur, Adam; Koch, Christoph M. et al.

Part of Genome Research, p. 708-719, 2007.

DOI for Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes

Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma

Thorleifsson, Gudmar; Magnusson, Kristinn P.; Sulem, Patrick; Walters, G. Bragi et al.

Part of Science, p. 1397-1400, 2007.

DOI for Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma

Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2)

Bakall, Benjamin; Radu, R.A.; Stanton, J. B.; Burke, J. M. et al.

Part of Experimental Eye Research, p. 34-43, 2007.

DOI for Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2)

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

Birney, Ewan; Stamatoyannopoulos, John A.; Dutta, Anindya; Guigó, Roderic et al.

Part of Nature, p. 799-816, 2007.

DOI for Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

In vitro analysis of DNA-protein interactions by proximity ligation

Gustafsdottir, Sigrun M.; Schlingemann, Jörg; Rada-Iglesias, Alvaro; Schallmeiner, Edith et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 3067-3072, 2007.

DOI for In vitro analysis of DNA-protein interactions by proximity ligation

Placental transfer of quetiapine in relation to P-glycoprotein activity

Rahi, Melissa; Heikkinen, Tuija; Härtter, Sebastian; Hakkola, Jukka et al.

Part of Journal of Psychopharmacology, p. 751-756, 2007.

DOI for Placental transfer of quetiapine in relation to P-glycoprotein activity

Expression of bestrophin-1, the product of the VMD2 gene, modulates voltage-dependent Ca2+ channels in retinal pigment epithelial cells

Rosenthal, Rita; Bakall, Benjamin; Kinnick, Tyson; Peachy, Neal et al.

Part of The FASEB Journal, p. 178-80, 2006.

DOI for Expression of bestrophin-1, the product of the VMD2 gene, modulates voltage-dependent Ca2+ channels in retinal pigment epithelial cells

Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays

Rada-Iglesias, Alvaro; Wallerman, Ola; Koch, Christoph; Ameur, Adam et al.

Part of Human Molecular Genetics, p. 3435-3447, 2005.

DOI for Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays

Common VKORC1 and GGCX polymorphisms associated with warfarin dose

Wadelius, Mia; Chen, L.Y.; Downes, K.; Ghori, J. et al.

Part of The Pharmacogenomics Journal, p. 262-70, 2005.

DOI for Common VKORC1 and GGCX polymorphisms associated with warfarin dose

Functional role of P-glycoprotein in the human blood-placental barrier

Mölsä, Melissa; Heikkinen, Tuija; Hakkola, Jukka; Hakala, Kristo et al.

Part of Clinical Pharmacology and Therapeutics, p. 123-31, 2005.

DOI for Functional role of P-glycoprotein in the human blood-placental barrier

Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors

Wadelius, Mia; Sörlin, Kristina; Wallerman, Ola; Karlsson, Jacob et al.

Part of The Pharmacogenomics Journal, p. 40-8, 2004.

DOI for Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors

Polymorphisms in NAT2, CYP2D6, CYP2C19 and GSTP1 and their association with prostate cancer

Wadelius, Mia; Autrup, J.L.; Stubbins, M.J.; Andersson, S.O. et al.

Part of Pharmacogenetics, p. 333-40, 1999.

Prostate cancer associated with CYP17 genotype

Wadelius, Mia; Andersson, S.O.; Johansson, J.E.; Wadelius, Claes et al.

Part of Pharmacogenetics, p. 635-9, 1999.

Lamotrigine and toxic epidermal necrolysis

Wadelius, Mia; Karlsson, Torbjörn; Wadelius, Claes; Rane, Anders

Part of The Lancet, p. 1041-, 1996.

DOI for Lamotrigine and toxic epidermal necrolysis

Molecular analysis of chromosome 21 in a patient with a phenotype of down syndrome and apparently normal karyotype

Edman Ahlbom, Bodil; Goetz, P; Korenberg, JR; Pettersson, Ulf et al.

Part of American Journal of Medical Genetics. Part A, p. 566-572, 1996.

DOI for Molecular analysis of chromosome 21 in a patient with a phenotype of down syndrome and apparently normal karyotype

Single Nuclei Transcriptome Analysis of Human Liver with Integration of Proteomics and Capture Hi-C Bulk Tissue Data

Cavalli, Marco; Diamanti, Klev; Pan, Gang; Rapolas, Spalinskas et al.