Publications in DiVA – Claes Wadelius
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Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
Part of Cell Reports Medicine, 2022.
DOI for Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues Download full text (pdf) of Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
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scSPLAT, a scalable plate-based protocol for single cell WGBS library preparation
Part of Scientific Reports, 2022.
DOI for scSPLAT, a scalable plate-based protocol for single cell WGBS library preparation Download full text (pdf) of scSPLAT, a scalable plate-based protocol for single cell WGBS library preparation
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Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate
Part of Pharmacogenomics (London), p. 973-982, 2021.
DOI for Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate Download full text (pdf) of Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate
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Polymorphisms rs55710213 and rs56334587 regulate SCD1 expression by modulating HNF4A binding
Part of Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, 2021.
DOI for Polymorphisms rs55710213 and rs56334587 regulate SCD1 expression by modulating HNF4A binding Download full text (pdf) of Polymorphisms rs55710213 and rs56334587 regulate SCD1 expression by modulating HNF4A binding
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Single nucleus transcriptomics data integration recapitulates the major cell types in human liver
Part of Hepatology Research, p. 233-238, 2021.
DOI for Single nucleus transcriptomics data integration recapitulates the major cell types in human liver Download full text (pdf) of Single nucleus transcriptomics data integration recapitulates the major cell types in human liver
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The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver
Part of Omics, p. 652-659, 2021.
DOI for The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver Download full text (pdf) of The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver
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A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human Liver
Part of Omics, p. 180-194, 2020.
DOI for A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human Liver Download full text (pdf) of A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human Liver
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Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
Part of Communications Biology, 2020.
DOI for Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis Download full text (pdf) of Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
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Combined burden and functional impact tests for cancer driver discovery using DriverPower
Part of Nature Communications, 2020.
DOI for Combined burden and functional impact tests for cancer driver discovery using DriverPower Download full text (pdf) of Combined burden and functional impact tests for cancer driver discovery using DriverPower
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Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment.
Part of The Pharmacogenomics Journal, p. 770-783, 2020.
DOI for Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment. Download full text (pdf) of Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment.
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Integration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes
Part of Scientific Reports, 2020.
DOI for Integration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes Download full text (pdf) of Integration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes
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Integrative pathway enrichment analysis of multivariate omics data.
Part of Nature Communications, 2020.
DOI for Integrative pathway enrichment analysis of multivariate omics data.
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Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Part of Nature Communications, 2020.
DOI for Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Download full text (pdf) of Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
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rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression
Part of iScience, 2020.
DOI for rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression Download full text (pdf) of rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression
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Sex differences in oncogenic mutational processes.
Part of Nature Communications, 2020.
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Allele specific chromatin signals, 3D interactions, and motif predictions for immune and B cell related diseases
Part of Scientific Reports, 2019.
DOI for Allele specific chromatin signals, 3D interactions, and motif predictions for immune and B cell related diseases Download full text (pdf) of Allele specific chromatin signals, 3D interactions, and motif predictions for immune and B cell related diseases
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Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation
Part of iScience, p. 42-59, 2019.
DOI for Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation Download full text (pdf) of Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation
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Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes
Part of Scientific Reports, 2019.
DOI for Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes Download full text (pdf) of Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes
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Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival
Part of EBioMedicine, p. 595-604, 2019.
DOI for Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival Download full text (pdf) of Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival
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Studies of liver tissue identify functional gene regulatory elements associated to gene expression, type 2 diabetes, and other metabolic diseases
Part of Human Genomics, 2019.
DOI for Studies of liver tissue identify functional gene regulatory elements associated to gene expression, type 2 diabetes, and other metabolic diseases Download full text (pdf) of Studies of liver tissue identify functional gene regulatory elements associated to gene expression, type 2 diabetes, and other metabolic diseases
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Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population
Part of Pharmacogenomics (London), p. 201-213, 2017.
DOI for Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population Download full text (pdf) of Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population
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PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c
Part of Nucleic Acids Research, p. 2408-2422, 2017.
DOI for PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c
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Allele-specific transcription factor binding in liver and cervix cells unveils many likely drivers of GWAS signals
Part of Genomics, p. 248-254, 2016.
DOI for Allele-specific transcription factor binding in liver and cervix cells unveils many likely drivers of GWAS signals Download full text (pdf) of Allele-specific transcription factor binding in liver and cervix cells unveils many likely drivers of GWAS signals
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Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression
Part of Human Genetics, p. 485-497, 2016.
DOI for Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression Download full text (pdf) of Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression
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Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy
Part of Pharmacogenomics (London), p. 1425-1439, 2016.
DOI for Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy Download full text (pdf) of Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy
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Looking beyond GWAS: allele-specific transcription factor binding drives the association of GALNT2 to HDL-C plasma levels
Part of Lipids in Health and Disease, 2016.
DOI for Looking beyond GWAS: allele-specific transcription factor binding drives the association of GALNT2 to HDL-C plasma levels Download full text (pdf) of Looking beyond GWAS: allele-specific transcription factor binding drives the association of GALNT2 to HDL-C plasma levels
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Maps of context-dependent putative regulatory regions and genomic signal interactions
Part of Nucleic Acids Research, p. 9110-9120, 2016.
DOI for Maps of context-dependent putative regulatory regions and genomic signal interactions Download full text (pdf) of Maps of context-dependent putative regulatory regions and genomic signal interactions
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Novel regulatory variant detected on the VKORC1 haplotype that is associated with warfarin dose
Part of Pharmacogenomics (London), p. 1305-1314, 2016.
DOI for Novel regulatory variant detected on the VKORC1 haplotype that is associated with warfarin dose Download full text (pdf) of Novel regulatory variant detected on the VKORC1 haplotype that is associated with warfarin dose
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Different distribution of histone modifications in genes with unidirectional and bidirectional transcription and a role of CTCF and cohesin in directing transcription
Part of BMC Genomics, 2015.
DOI for Different distribution of histone modifications in genes with unidirectional and bidirectional transcription and a role of CTCF and cohesin in directing transcription Download full text (pdf) of Different distribution of histone modifications in genes with unidirectional and bidirectional transcription and a role of CTCF and cohesin in directing transcription
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Best vitelliform macular dystrophy in a Swedish family: genetic analysis and a seven-year follow-up of photodynamic treatment of a young boy with choroidal neovascularization
Part of Acta Ophthalmologica, p. 238-242, 2014.
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Integration of genome-wide of Stat3 binding and epigenetic modification mapping with transcriptome reveals novel Stat3 target genes in glioma cells
Part of Biochimica et Biophysica Acta, p. 1341-1350, 2014.
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Nucleosome regulatory dynamics in response to TGF beta
Part of Nucleic Acids Research, p. 6921-6934, 2014.
DOI for Nucleosome regulatory dynamics in response to TGF beta
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Nucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells
Part of Nucleic Acids Research, p. 6921-6934, 2014.
DOI for Nucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells
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ChIP-seq in steatohepatitis and normal liver tissue identifies candidate disease mechanisms related to progression to cancer
Part of BMC Medical Genomics, p. 50-, 2013.
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A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements
Part of Algorithms for Molecular Biology, p. 2-, 2012.
DOI for A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements Download full text (pdf) of A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements
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Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa
Part of BMC Cancer, p. 450-, 2011.
DOI for Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa Download full text (pdf) of Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa
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Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma
Part of Nature Genetics, p. 906-909, 2010.
DOI for Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma
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Integrative epigenomic and genomic analysis of malignant pheochromocytoma.
Part of Experimental and Molecular Medicine, p. 484-502, 2010.
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Integrative epigenomic and genomic analysis of malignant pheochromocytoma
Part of Experimental and Molecular Medicine, p. 484-502, 2010.
DOI for Integrative epigenomic and genomic analysis of malignant pheochromocytoma
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Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq
Part of Genome Biology, p. R129-, 2009.
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Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation
Part of Epigenetics, p. 107-113, 2009.
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Identification of candidate regulatory SNPs by combination of transcription-factor-binding site prediction, SNP genotyping and haploChIP
Part of Nucleic Acids Research, p. e85-, 2009.
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Integrating genome and epigenome in human disease
Part of Epigenomics, p. 343-368, 2009.
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Nucleosomes are well positioned in exons and carry characteristic histone modifications
Part of Genome Research, p. 1732-1741, 2009.
DOI for Nucleosomes are well positioned in exons and carry characteristic histone modifications
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Two polypyrimidine tracts in the nitric oxide synthase 2 gene: similar regulatory sequences with different properties.
Part of Molecular Biology Reports, p. 2021-2030, 2009.
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Influence of adenosine triphosphate and ABCB1 (MDR1) genotype on the P-glycoprotein-dependent transfer of saquinavir in the dually perfused human placenta
Part of Human and Experimental Toxicology, p. 65-71, 2008.
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Monte Carlo feature selection for supervised classification
Part of Bioinformatics, p. 110-117, 2008.
DOI for Monte Carlo feature selection for supervised classification
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ORegAnno: an open-access community-driven resource for regulatory annotation
Part of Nucleic Acids Research, p. D107-D113, 2008.
DOI for ORegAnno: an open-access community-driven resource for regulatory annotation
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Whole-genome maps of USF1 and USF2 binding and histone H3 acetylation reveal new aspects of promoter structure and candidate genes for common human disorders
Part of Genome Research, p. 380-392, 2008.
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Association of warfarin dose with genes involved in its action and metabolism
Part of Human Genetics, p. 23-34, 2007.
DOI for Association of warfarin dose with genes involved in its action and metabolism
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Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes
Part of Genome Research, p. 708-719, 2007.
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Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2)
Part of Experimental Eye Research, p. 34-43, 2007.
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In vitro analysis of DNA-protein interactions by proximity ligation
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 3067-3072, 2007.
DOI for In vitro analysis of DNA-protein interactions by proximity ligation
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Placental transfer of quetiapine in relation to P-glycoprotein activity
Part of Journal of Psychopharmacology, p. 751-756, 2007.
DOI for Placental transfer of quetiapine in relation to P-glycoprotein activity
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Expression of bestrophin-1, the product of the VMD2 gene, modulates voltage-dependent Ca2+ channels in retinal pigment epithelial cells
Part of The FASEB Journal, p. 178-80, 2006.
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Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays
Part of Human Molecular Genetics, p. 3435-3447, 2005.
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Common VKORC1 and GGCX polymorphisms associated with warfarin dose
Part of The Pharmacogenomics Journal, p. 262-70, 2005.
DOI for Common VKORC1 and GGCX polymorphisms associated with warfarin dose
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Functional role of P-glycoprotein in the human blood-placental barrier
Part of Clinical Pharmacology and Therapeutics, p. 123-31, 2005.
DOI for Functional role of P-glycoprotein in the human blood-placental barrier
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Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors
Part of The Pharmacogenomics Journal, p. 40-8, 2004.
DOI for Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors
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Polymorphisms in NAT2, CYP2D6, CYP2C19 and GSTP1 and their association with prostate cancer
Part of Pharmacogenetics, p. 333-40, 1999.
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Prostate cancer associated with CYP17 genotype
Part of Pharmacogenetics, p. 635-9, 1999.
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Lamotrigine and toxic epidermal necrolysis
Part of The Lancet, p. 1041-, 1996.
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Molecular analysis of chromosome 21 in a patient with a phenotype of down syndrome and apparently normal karyotype
Part of American Journal of Medical Genetics. Part A, p. 566-572, 1996.