Vascular biology

Microscope image showing the growth of blood vessels in vitroThe formation of new blood vessels, angiogenesis, is an important and strictly controlled process that under normal circumstances takes place during embryonic development, in wound healing and in the female menstruation cycle. However, in several diseases, for instance cancer, there is an exaggerated angiogenesis that leads to a disorganized and dysfunctional vasculature that may propagate the disease.

In the research programme Vascular Biology we study how angiogenesis is regulated, both during embryo development, in adults and in diseases, mainly cancer. We are particularly interested in how growth factors and other regulating proteins stimulate or inhibit angiogenesis during development, and how vessel permeability to molecules and cells is regulated in the CNS and in peripheral organs. We also study the mechanisms behind the formation of lymphatic vessels and how they function.

Research groups