Publications in DiVA – Elisabetta Dejana

CD93 maintains endothelial barrier function by limiting the phosphorylation and turnover of VE-cadherin

Lugano, Roberta; Vemuri, Kalyani; Barbera, Stefano; Orlandini, Maurizio et al.

Part of The FASEB Journal, 2023.

DOI for CD93 maintains endothelial barrier function by limiting the phosphorylation and turnover of VE-cadherin Download full text (pdf) of CD93 maintains endothelial barrier function by limiting the phosphorylation and turnover of VE-cadherin

A murine model of cerebral cavernous malformations with acute hemorrhage

Maderna, Claudio; Pisati, Federica; Tripodo, Claudio; Dejana, Elisabetta et al.

Part of iScience, 2022.

DOI for A murine model of cerebral cavernous malformations with acute hemorrhage Download full text (pdf) of A murine model of cerebral cavernous malformations with acute hemorrhage

Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells

Rath, Matthias; Schwefel, Konrad; Malinverno, Matteo; Skowronek, Dariush et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2022.

DOI for Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells Download full text (pdf) of Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells

Immunothrombosis and vascular heterogeneity in cerebral cavernous malformation

Globisch, Maria A.; Onyeogaziri, Favour C.; Jauhiainen, Suvi; Yau, Anthony C. Y. et al.

Part of Blood, p. 2154-2169, 2022.

DOI for Immunothrombosis and vascular heterogeneity in cerebral cavernous malformation Download full text (pdf) of Immunothrombosis and vascular heterogeneity in cerebral cavernous malformation

Inflammation and neutrophil extracellular traps in cerebral cavernous malformation

Yau, Anthony C. Y.; Globisch, Maria A.; Onyeogaziri, Favour; Conze, Lei Liu et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2022.

DOI for Inflammation and neutrophil extracellular traps in cerebral cavernous malformation Download full text (pdf) of Inflammation and neutrophil extracellular traps in cerebral cavernous malformation

Inflammation and neutrophil extracellular traps in cerebral cavernous malformation (vol 79, 206, 2022)

Yau, Anthony C. Y.; Globisch, Maria A.; Onyeogaziri, Favour; Conze, Lei L. et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2022.

DOI for Inflammation and neutrophil extracellular traps in cerebral cavernous malformation (vol 79, 206, 2022) Download full text (pdf) of Inflammation and neutrophil extracellular traps in cerebral cavernous malformation (vol 79, 206, 2022)

A dual role of YAP in driving TGF beta-mediated endothelial-to-mesenchymal transition

Savorani, Cecilia; Malinverno, Matteo; Seccia, Roberta; Maderna, Claudio et al.

Part of Journal of Cell Science, 2021.

DOI for A dual role of YAP in driving TGF beta-mediated endothelial-to-mesenchymal transition

Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion

Monzo, Pascale; Crestani, Michele; Chong, Yuk Kien; Ghisleni, Andrea et al.

Part of Developmental Cell, p. 2841-2855.e8, 2021.

DOI for Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion Download full text (pdf) of Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion

ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.

Huang, Hua; Georganaki, Maria; Conze, Lei Liu; Laviña, Bàrbara et al.

Part of Neuro-Oncology, p. 398-411, 2021.

DOI for ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma. Download full text (pdf) of ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.

Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies

Claesson-Welsh, Lena; Dejana, Elisabetta; McDonald, Donald M.

Part of Trends in Molecular Medicine, p. 314-331, 2021.

DOI for Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies Download full text (pdf) of Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies

Propranolol Reduces the Development of Lesions and Rescues Barrier Function in Cerebral Cavernous Malformations: A Preclinical Study

Oldenburg, Joppe; Malinverno, Matteo; Globisch, Maria A.; Maderna, Claudio et al.

Part of Stroke, p. 1418-1427, 2021.

DOI for Propranolol Reduces the Development of Lesions and Rescues Barrier Function in Cerebral Cavernous Malformations: A Preclinical Study

The multifaceted PDCD10/CCM3 gene

Valentino, Mariaelena; Dejana, Elisabetta; Malinverno, Matteo

Part of Genes & Diseases, p. 798-813, 2021.

DOI for The multifaceted PDCD10/CCM3 gene Download full text (pdf) of The multifaceted PDCD10/CCM3 gene

c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly

Schimmel, Lilian; Fukuhara, Daisuke; Richards, Mark; Jin, Yi et al.

Part of Development, 2020.

DOI for c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly Download full text (pdf) of c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly

JAM-A Acts via C/EBP-alpha to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function

Kakogiannos, Nikolaos; Ferrari, Laura; Giampietro, Costanza; Scalise, Anna Agata et al.

Part of Circulation Research, p. 1056-1073, 2020.

DOI for JAM-A Acts via C/EBP-alpha to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function Download full text (pdf) of JAM-A Acts via C/EBP-alpha to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function

Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution

Orsenigo, Fabrizio; Conze, Lei Liu; Jauhiainen, Suvi; Corada, Monica et al.

Part of eLIFE, 2020.

DOI for Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution Download full text (pdf) of Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution

Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin

Smith, Ross O.; Ninchoji, Takeshi; Gordon, Emma; Andre, Helder et al.

Part of eLIFE, 2020.

DOI for Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin Download full text (pdf) of Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin

A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing

Angiolini, Francesca; Belloni, Elisa; Giordano, Marco; Campioni, Matteo et al.

Part of eLIFE, 2019.

DOI for A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing Download full text (pdf) of A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing

CDC42 deletion elicits cerebral vascular malformations via increased MEKK3-dependent KLF4 expression

Castro, Marco; Laviña, Bàrbara; Ando, Koji; Alvarez-Aznar, Alberto et al.

Part of Circulation Research, p. 1240-1252, 2019.

DOI for CDC42 deletion elicits cerebral vascular malformations via increased MEKK3-dependent KLF4 expression

Emerging Pharmacologic Targets in Cerebral Cavernous Malformation and Potential Strategies to Alter the Natural History of a Difficult Disease: A Review

Chohan, Muhammad O.; Marchio, Serena; Morrison, Leslie A.; Sidman, Richard L. et al.

Part of JAMA Neurology, p. 492-500, 2019.

DOI for Emerging Pharmacologic Targets in Cerebral Cavernous Malformation and Potential Strategies to Alter the Natural History of a Difficult Disease: A Review

Endothelial beta-Catenin Signaling Supports Postnatal Brain and Retinal Angiogenesis by Promoting Sprouting, Tip Cell Formation, and VEGFR (Vascular Endothelial Growth Factor Receptor) 2 Expression

Martowicz, Agnieszka; Trusohamn, Marta; Jensen, Nina; Wisniewska-Kruk, Joanna et al.

Part of Arteriosclerosis, Thrombosis and Vascular Biology, p. 2273-2288, 2019.

DOI for Endothelial beta-Catenin Signaling Supports Postnatal Brain and Retinal Angiogenesis by Promoting Sprouting, Tip Cell Formation, and VEGFR (Vascular Endothelial Growth Factor Receptor) 2 Expression

Endothelial cell clonal expansion in the development of cerebral cavernous malformations

Malinverno, Matteo; Maderna, Claudio; Abu Taha, Abdallah; Corada, Monica et al.

Part of Nature Communications, 2019.

DOI for Endothelial cell clonal expansion in the development of cerebral cavernous malformations Download full text (pdf) of Endothelial cell clonal expansion in the development of cerebral cavernous malformations

Fine-Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier

Corada, Monica; Orsenigo, Fabrizio; Bhat, Ganesh Parameshwar; Conze, Lei Liu et al.

Part of Circulation Research, p. 511-525, 2019.

DOI for Fine-Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier Download full text (pdf) of Fine-Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier

Transient Photoinactivation of Cell Membrane Protein Activity without Genetic Modification by Molecular Hyperthermia

Kang, Peiyuan; Li, Xiaoqing; Liu, Yaning; Shiers, Stephanie I. et al.

Part of ACS Nano, p. 12487-12499, 2019.

DOI for Transient Photoinactivation of Cell Membrane Protein Activity without Genetic Modification by Molecular Hyperthermia

CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis

Lugano, Roberta; Vemuri, Kalyani; Yu, Di; Bergqvist, Michael et al.

Part of Journal of Clinical Investigation, p. 3280-3297, 2018.

DOI for CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis Download full text (pdf) of CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis

Endothelial cell transitions

Dejana, Elisabetta; Lampugnani, Maria Grazia

Part of Science, p. 746-747, 2018.

DOI for Endothelial cell transitions

Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling

Krispin, Shlomo; Stratman, Amber N.; Melick, Chase H.; Stan, Radu V. et al.

Part of Arteriosclerosis, Thrombosis and Vascular Biology, p. 353-362, 2018.

DOI for Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling

Resident Endothelial Progenitors Make Themselves at Home

Hirschi, Karen K.; Dejana, Elisabetta

Part of Cell Stem Cell, p. 153-155, 2018.

DOI for Resident Endothelial Progenitors Make Themselves at Home

Vascular Endothelial (VE)-Cadherin, Endothelial Adherens Junctions, and Vascular Disease

Lampugnani, Maria Grazia; Dejana, Elisabetta; Giampietro, Costanza

Part of Cold Spring Harbor Perspectives in Biology, 2018.

DOI for Vascular Endothelial (VE)-Cadherin, Endothelial Adherens Junctions, and Vascular Disease

VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression

Morini, Marco F.; Giampietro, Costanza; Corada, Monica; Pisati, Federica et al.

Part of Circulation Research, p. 231-245, 2018.

DOI for VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression Download full text (pdf) of VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression

Deregulated TGF-beta/BMP Signaling in Vascular Malformations

Cunha, Sara I.; Magnusson, Peetra; Dejana, Elisabetta; Lampugnani, Maria Grazia

Part of Circulation Research, p. 981-999, 2017.

DOI for Deregulated TGF-beta/BMP Signaling in Vascular Malformations

Endothelial cell disease: emerging knowledge from cerebral cavernous malformations

Lampugnani, Maria Grazia; Malinverno, Matteo; Dejana, Elisabetta; Rudini, Noemi

Part of Current opinion in hematology, p. 256-264, 2017.

DOI for Endothelial cell disease: emerging knowledge from cerebral cavernous malformations

Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis

Erba, Benedetta Gaia; Gruppi, Cristian; Corada, Monica; Pisati, Federica et al.

Part of American Journal of Pathology, p. 1879-1892, 2017.

DOI for Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis Download full text (pdf) of Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis

Peg3/PW1 Is a Marker of a Subset of Vessel Associated Endothelial Progenitors

Malinverno, Matteo; Corada, Monica; Ferrarini, Luca; Formicola, Luigi et al.

Part of Stem Cells, p. 1328-1340, 2017.

DOI for Peg3/PW1 Is a Marker of a Subset of Vessel Associated Endothelial Progenitors

SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development

Chiang, Ivy Kim-Ni; Fritzsche, Martin; Pichol-Thievend, Cathy; Neal, Alice et al.

Part of Development, p. 2629-2639, 2017.

DOI for SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development

The molecular basis of endothelial cell plasticity

Dejana, Elisabetta; Hirschi, Karen K.; Simons, Michael

Part of Nature Communications, 2017.

DOI for The molecular basis of endothelial cell plasticity Download full text (pdf) of The molecular basis of endothelial cell plasticity

beta-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function

Ziegler, Nicole; Awwad, Khader; Fisslthaler, Beate; Reis, Marco et al.

Part of Journal of Neuroscience, p. 8921-8935, 2016.

DOI for beta-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function

Endothelial Cells Lining Sporadic Cerebral Cavernous Malformation Cavernomas Undergo Endothelial-to-Mesenchymal Transition

Bravi, Luca; Malinverno, Matteo; Pisati, Federica; Rudini, Noemi et al.

Part of Stroke, p. 886-890, 2016.

DOI for Endothelial Cells Lining Sporadic Cerebral Cavernous Malformation Cavernomas Undergo Endothelial-to-Mesenchymal Transition

Glycolytic regulation of cell rearrangement in angiogenesis

Cruys, Bert; Wong, Brian W.; Kuchnio, Anna; Verdegem, Dries et al.

Part of Nature Communications, 2016.

DOI for Glycolytic regulation of cell rearrangement in angiogenesis Download full text (pdf) of Glycolytic regulation of cell rearrangement in angiogenesis

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations

Cuttano, Roberto; Rudini, Noemi; Bravi, Luca; Corada, Monica et al.

Part of EMBO Molecular Medicine, p. 6-24, 2016.

DOI for KLF4 is a key determinant in the development and progression of cerebral cavernous malformations Download full text (pdf) of KLF4 is a key determinant in the development and progression of cerebral cavernous malformations

Oligodendrocytes follow blood vessel trails in the brain Brain microvasculature is a scaffold for neuroglial migration

Dejana, Elisabetta; Betsholtz, Christer

Part of Science, p. 341-342, 2016.

DOI for Oligodendrocytes follow blood vessel trails in the brain Brain microvasculature is a scaffold for neuroglial migration

Partial loss of VE-cadherin improves long-term outcome and cerebral blood flow after transient brain ischemia in mice

Gertz, Karen; Kronenberg, Golo; Uhlemann, Ria; Prinz, Vincent et al.

Part of BMC Neurology, 2016.

DOI for Partial loss of VE-cadherin improves long-term outcome and cerebral blood flow after transient brain ischemia in mice Download full text (pdf) of Partial loss of VE-cadherin improves long-term outcome and cerebral blood flow after transient brain ischemia in mice

The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation

Gordon, Emma J.; Fukuhara, Daisuke; Weström, Simone; Padhan, Narendra et al.

Part of Science Signaling, 2016.

DOI for The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation

VE-cadherin modulates YAP intracellular localization and signalling

Giampietro, C.; Disanza, A.; Scita, G.; Dejana, Elisabetta

Part of The FEBS Journal, p. 48-48, 2016.

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

Li, Xiujuan; Padhan, Narendra; Sjöström, Elisabet O.; Roche, Francis P. et al.

Part of Nature Communications, 2016.

DOI for VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread Download full text (pdf) of VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

A gut-vascular barrier controls the systemic dissemination of bacteria

Spadoni, Ilaria; Zagato, Elena; Bertocchi, Alice; Paolinelli, Roberta et al.

Part of Science, p. 830-834, 2015.

DOI for A gut-vascular barrier controls the systemic dissemination of bacteria

Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice

Bravi, Luca; Rudini, Noemi; Cuttano, Roberto; Giampietro, Costanza et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 8421-8426, 2015.

DOI for Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice

The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling

Giampietro, Costanza; Disanza, Andrea; Bravi, Luca; Barrios-Rodiles, Miriam et al.

Part of Journal of Cell Biology, p. 1177-1192, 2015.

DOI for The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling

The alternative splicing factor Nova2 regulates vascular development and lumen formation

Giampietro, Costanza; Deflorian, Gianluca; Gallo, Stefania; Di Matteo, Anna et al.

Part of Nature Communications, 2015.

DOI for The alternative splicing factor Nova2 regulates vascular development and lumen formation Download full text (pdf) of The alternative splicing factor Nova2 regulates vascular development and lumen formation