Publications in DiVA – Taija Mäkinen

APOLD1 loss causes endothelial dysfunction involving cell junctions, cytoskeletal architecture, and Weibel-Palade bodies, while disrupting hemostasis

Stritt, Simon; Nurden, Paquita; Nurden, Alan T.; Schved, Jean-François et al.

Part of Haematologica, p. 772-784, 2023.

DOI for APOLD1 loss causes endothelial dysfunction involving cell junctions, cytoskeletal architecture, and Weibel-Palade bodies, while disrupting hemostasis Download full text (pdf) of APOLD1 loss causes endothelial dysfunction involving cell junctions, cytoskeletal architecture, and Weibel-Palade bodies, while disrupting hemostasis

Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

Petkova, Milena; Kraft, Marle; Stritt, Simon; Martinez-Corral, Ines et al.

Part of Journal of Experimental Medicine, 2023.

DOI for Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation Download full text (pdf) of Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium

Singhal, Dhruv; Börner, Katy; Chaikof, Elliot L.; Detmar, Michael et al.

Part of Frontiers in Physiology, 2023.

DOI for Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium Download full text (pdf) of Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium

Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells

Chen, Di; Hughes, Elizabeth D.; Saunders, Thomas L.; Wu, Jiangping et al.

Part of JCI Insight, 2022.

DOI for Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells Download full text (pdf) of Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells

Cellular Origin of Sporadic CCMs

Betsholtz, Christer; Gängel, Konstantin; Mäkinen, Taija

Part of New England Journal of Medicine, p. 1291-1291, 2022.

DOI for Cellular Origin of Sporadic CCMs

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Korhonen, Emilia A.; Murtomäki, Aino; Jha, Sawan Kumar; Anisimov, Andrey et al.

Part of Journal of Clinical Investigation, 2022.

DOI for Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression Download full text (pdf) of Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research

Muhl, Lars; He, Liqun; Sun, Ying; Andaloussi Mäe, Maarja et al.

Part of Stem Cell Reports, p. 1089-1104, 2022.

DOI for The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research

An inducible Cldn11-CreER^T2 mouse line for selective targeting of lymphatic valves

Ortsäter, Henrik; Hernández-Vásquez, Magda N.; Ulvmar, Maria H.; Gow, Alexander et al.

Part of Genesis, 2021.

DOI for An inducible Cldn11-CreER^T2 mouse line for selective targeting of lymphatic valves Download full text (pdf) of An inducible Cldn11-CreER^T2 mouse line for selective targeting of lymphatic valves

Homeostatic maintenance of the lymphatic vasculature

Stritt, Simon; Koltowska, Katarzyna; Mäkinen, Taija

Part of Trends in Molecular Medicine, p. 955-970, 2021.

DOI for Homeostatic maintenance of the lymphatic vasculature Download full text (pdf) of Homeostatic maintenance of the lymphatic vasculature

Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies

Mäkinen, Taija; Boon, Laurence M.; Vikkula, Miikka; Alitalo, Kari

Part of Circulation Research, p. 136-154, 2021.

DOI for Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies

Mutations in EPHB4 cause human venous valve aplasia

Lyons, Oliver; Walker, James; Seet, Christopher; Ikram, Mohammed et al.

Part of JCI Insight, 2021.

DOI for Mutations in EPHB4 cause human venous valve aplasia Download full text (pdf) of Mutations in EPHB4 cause human venous valve aplasia

Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels

Hernández Vásquez, Magda; Ulvmar, Maria H.; González-Loyola, Alejandra; Kritikos, Ioannis et al.

Part of EMBO Journal, 2021.

DOI for Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels Download full text (pdf) of Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels

Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation

Arasa, Jorge; Collado-Diaz, Victor; Kritikos, Ioannis; Medina-Sanchez, Jessica Danielly et al.

Part of Journal of Experimental Medicine, 2021.

DOI for Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation

Martinez-Corral, Ines; Zhang, Yan; Petkova, Milena; Ortsäter, Henrik et al.

Part of Nature Communications, 2020.

DOI for Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation Download full text (pdf) of Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation

EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity

Frye, Maike; Stritt, Simon; Ortsäter, Henrik; Hernandez Vasquez, Magda et al.

Part of eLIFE, 2020.

DOI for EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity Download full text (pdf) of EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity

Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER(T2) lines

Alvarez, Alberto; Martinez-Corral, Ines; Daubel, Nina; Betsholtz, Christer et al.

Part of Transgenic research, p. 53-68, 2020.

DOI for Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER(T2) lines Download full text (pdf) of Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER(T2) lines

Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages

Suh, Sang Heon; Choe, Kibaek; Hong, Seon Pyo; Jeong, Seung-hwan et al.

Part of EMBO Reports, 2019.

DOI for Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages

Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth

Urner, Sofia; Planas-Paz, Lara; Hilger, Laura Sophie; Henning, Carina et al.

Part of EMBO Journal, 2019.

DOI for Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth

Neurobiology: A Drain At The Base Of The Brain

Mäkinen, Taija

Part of Nature, p. 34-35, 2019.

DOI for Neurobiology: A Drain At The Base Of The Brain

YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis

Cho, Hyunsoo; Kim, Jaeryung; Ahn, Ji Hoon; Hong, Young-Kwon et al.

Part of Circulation Research, p. 225-242, 2019.

DOI for YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis

Distinct roles of VE-cadherin for development and maintenance of specific lymph vessel beds

Haegerling, Rene; Hoppe, Esther; Dierkes, Cathrin; Stehling, Martin et al.

Part of EMBO Journal, 2018.

DOI for Distinct roles of VE-cadherin for development and maintenance of specific lymph vessel beds

Genetic Lineage Tracing of Lymphatic Endothelial Cells in Mice.

Martinez-Corral, Ines; Mäkinen, Taija

Part of Methods in Molecular Biology, p. 37-53, 2018.

DOI for Genetic Lineage Tracing of Lymphatic Endothelial Cells in Mice.

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms

Zhang, Yan; Ulvmar, Maria H.; Stanczuk, Lukas; Martinez-Corral, Ines et al.

Part of Nature Communications, 2018.

DOI for Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms Download full text (pdf) of Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms

Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

Frye, Maike; Taddei, Andrea; Dierkes, Cathrin; Martinez-Corral, Ines et al.

Part of Nature Communications, 2018.

DOI for Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program Download full text (pdf) of Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

PROX1 is a transcriptional regulator of MMP14

Gramolelli, Silvia; Cheng, Jianpin; Martinez-Corral, Ines; Vaha-Koskela, Markus et al.

Part of Scientific Reports, 2018.

DOI for PROX1 is a transcriptional regulator of MMP14 Download full text (pdf) of PROX1 is a transcriptional regulator of MMP14

Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels

Zhang, Yang; Daubel, Nina; Stritt, Simon; Mäkinen, Taija

Part of Development, 2018.

DOI for Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels

Dachsousl-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report

Pujol, Francoise; Hodgson, Tina; Martinez-Corral, Ines; Prats, Anne-Catherine et al.

Part of Arteriosclerosis, Thrombosis and Vascular Biology, p. 1732-1735, 2017.

DOI for Dachsousl-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report

Human Venous Valve Disease Caused by Mutations in FOXC2 and GJC2

Lyons, Oliver; Saha, Prakash; Seet, Christopher; Kuchta, Adam et al.

Part of Journal of Vascular Research, p. 62-62, 2017.

Human venous valve disease caused by mutations in FOXC2 and GJC2

Lyons, Oliver; Saha, Prakash; Seet, Christopher; Kuchta, Adam et al.

Part of Journal of Experimental Medicine, p. 2437-2452, 2017.

DOI for Human venous valve disease caused by mutations in FOXC2 and GJC2 Download full text (pdf) of Human venous valve disease caused by mutations in FOXC2 and GJC2

Lymphangiogenesis guidance by paracrine and pericellular factors

Vaahtomeri, Kari; Karaman, Sinem; Mäkinen, Taija; Alitalo, Kari

Part of Genes & Development, p. 1615-1634, 2017.

DOI for Lymphangiogenesis guidance by paracrine and pericellular factors Download full text (pdf) of Lymphangiogenesis guidance by paracrine and pericellular factors

Mechanisms underlying human venous valve disease caused by mutations in Foxc2 and connexin47

Lyons, O. T. A.; Saha, P.; Seet, C.; Kuchta, A. et al.

Part of British Journal of Surgery, p. 8-8, 2017.

DOI for Mechanisms underlying human venous valve disease caused by mutations in Foxc2 and connexin47

Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity

Wang, Yixin; Jin, Yi; Mäe, Maarja Andaloussi; Zhang, Yang et al.

Part of Development, p. 3590-3601, 2017.

DOI for Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity

Vascular heterogeneity and specialization in development and disease

Potente, Michael; Mäkinen, Taija

Part of Nature reviews. Molecular cell biology, p. 477-494, 2017.

DOI for Vascular heterogeneity and specialization in development and disease Download full text (pdf) of Vascular heterogeneity and specialization in development and disease

EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis

Martin-Almedina, Silvia; Martinez-Corral, Ines; Holdhus, Rita; Vicente, Andres et al.

Part of Journal of Clinical Investigation, p. 3080-3088, 2016.

DOI for EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis Download full text (pdf) of EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis

Heterogeneity in the lymphatic vascular system and its origin

Ulvmar, Maria H.; Mäkinen, Taija

Part of Cardiovascular Research, p. 310-321, 2016.

DOI for Heterogeneity in the lymphatic vascular system and its origin Download full text (pdf) of Heterogeneity in the lymphatic vascular system and its origin

Lymphatic System in Cardiovascular Medicine

Aspelund, Aleksanteri; Robciuc, Marius R.; Karaman, Sinem; Mäkinen, Taija et al.

Part of Circulation Research, p. 515-530, 2016.

DOI for Lymphatic System in Cardiovascular Medicine

Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins

Ulvmar, Maria H; Martinez-Corral, Ines; Stanczuk, Lukas; Mäkinen, Taija

Part of Genesis, p. 350-358, 2016.

DOI for Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins

Vegfr3-CreER (T2) mouse, a new genetic tool for targeting the lymphatic system

Martinez-Corral, Ines; Stanczuk, Lukas; Frye, Maike; Ulvmar, Maria Helena et al.

Part of Angiogenesis, p. 433-445, 2016.

DOI for Vegfr3-CreER (T2) mouse, a new genetic tool for targeting the lymphatic system Download full text (pdf) of Vegfr3-CreER (T2) mouse, a new genetic tool for targeting the lymphatic system

A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research

Bianchi, Roberta; Teijeira, Alvaro; Proulx, Steven T.; Christiansen, Ailsa J. et al.

Part of PLOS ONE, 2015.

DOI for A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research Download full text (pdf) of A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels

Stanczuk, Lukas; Martinez-Corral, Ines; Ulvmar, Maria H.; Zhang, Yang et al.

Part of Cell reports, p. 1708-1721, 2015.

DOI for cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels Download full text (pdf) of cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels

FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature

Sabine, Amelie; Bovay, Esther; Demir, Cansaran Saygili; Kimura, Wataru et al.

Part of Journal of Clinical Investigation, p. 3861-3877, 2015.

DOI for FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature

Nonvenous Origin of Dermal Lymphatic Vasculature

Martinez-Corral, Ines; Ulvmar, Maria H.; Stanczuk, Lukas; Tatin, Florence et al.

Part of Circulation Research, p. 1649-1654, 2015.

DOI for Nonvenous Origin of Dermal Lymphatic Vasculature

Organ-Specific Origins of Lymphatic Vasculature

Mäkinen, Taija

Part of Journal of Vascular Research, p. 18-19, 2015.

Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction

Rouhani, Sherin J.; Eccles, Jacob D.; Riccardi, Priscila; Peske, J. David et al.

Part of Nature Communications, 2015.

DOI for Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction

Therapeutic Insights to Lymphangiogenic Growth Factors

Aspelund, Aleksanteri; Tammela, Tuomas; Antila, Salli; Nurmi, Harri et al.

Part of Journal of Vascular Research, p. 19-19, 2015.

VEGFR3 does not sustain retinal angiogenesis without VEGFR2

Zarkada, Georgia; Heinolainen, Krista; Mäkinen, Taija; Kubota, Yoshiaki et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 761-766, 2015.

DOI for VEGFR3 does not sustain retinal angiogenesis without VEGFR2

Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity

Park, Dae-Young; Lee, Junyeop; Park, Intae; Choi, Dongwon et al.

Part of Journal of Clinical Investigation, p. 3960-3974, 2014.

DOI for Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity

Lymphatic vascular morphogenesis

Tatin, Florence; Mäkinen, Taija

Part of Molecular Mechanisms of Angiogenesis, p. 25-44, 2014.

DOI for Lymphatic vascular morphogenesis

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.

Hess, Paul R; Rawnsley, David R; Jakus, Zoltán; Yang, Yiqing et al.

Part of Journal of Clinical Investigation, 2014.

DOI for Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.

Regulation of Lymphatic Vasculature by Extracellular Matrix

Lutter, Sophie; Mäkinen, Taija

Part of Developmental Aspects of the Lymphatic Vascular System, p. 55-65, 2014.

DOI for Regulation of Lymphatic Vasculature by Extracellular Matrix

The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel

Aspelund, Aleksanteri; Tammela, Tuomas; Antila, Salli; Nurmi, Harri et al.

Part of Journal of Clinical Investigation, p. 3975-3986, 2014.

DOI for The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel

Adrenomedullin haploinsufficiency predisposes to secondary lymphedema.

Nikitenko, Leonid L; Shimosawa, Tatsuo; Henderson, Stephen; Mäkinen, Taija et al.

Part of Journal of Investigative Dermatology, 2013.

DOI for Adrenomedullin haploinsufficiency predisposes to secondary lymphedema.

Flow control in our vessels: vascular valves make sure there is no way back.

Bazigou, Eleni; Mäkinen, Taija

Part of Cellular and Molecular Life Sciences (CMLS), 2013.

DOI for Flow control in our vessels: vascular valves make sure there is no way back.

Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis.

Tatin, Florence; Taddei, Andrea; Weston, Anne; Fuchs, Elaine et al.

Part of Developmental Cell, 2013.

DOI for Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis.

Regulation of lymphatic vascular morphogenesis: Implications for pathological (tumor) lymphangiogenesis

Martinez-Corral, Ines; Mäkinen, Taija

Part of Experimental Cell Research, p. 1618-1625, 2013.

DOI for Regulation of lymphatic vascular morphogenesis: Implications for pathological (tumor) lymphangiogenesis

Blood flow reprograms lymphatic vessels to blood vessels.

Chen, Chiu-Yu; Bertozzi, Cara; Zou, Zhiying; Yuan, Lijun et al.

Part of Journal of Clinical Investigation, 2012.

DOI for Blood flow reprograms lymphatic vessels to blood vessels.

Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.

Sabine, Amélie; Agalarov, Yan; Maby-El Hajjami, Hélène; Jaquet, Muriel et al.

Part of Developmental Cell, 2012.

DOI for Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.

Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.

Ostergaard, Pia; Simpson, Michael A; Mendola, Antonella; Vasudevan, Pradeep et al.

Part of American Journal of Human Genetics, 2012.

DOI for Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.

Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development

Wallgard, Elisabet; Nitzsche, Anja; Larsson, Jimmy; Guo, Xiaoyuan et al.

Part of Developmental Dynamics, p. 770-786, 2012.

DOI for Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development

Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation.

Lutter, Sophie; Xie, Sherry; Tatin, Florence; Mäkinen, Taija

Part of Journal of Cell Biology, 2012.

DOI for Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation.

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice.

Bazigou, Eleni; Lyons, Oliver T A; Smith, Alberto; Venn, Graham E et al.

Part of Journal of Clinical Investigation, 2011.

DOI for Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice.

Mutations in FOXC2 in humans (lymphoedema distichiasis syndrome) cause lymphatic dysfunction on dependency.

Mellor, Russell H; Tate, Naomi; Stanton, Anthony W B; Hubert, Charlotte et al.

Part of Journal of Vascular Research, 2011.

DOI for Mutations in FOXC2 in humans (lymphoedema distichiasis syndrome) cause lymphatic dysfunction on dependency.

Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome).

Ostergaard, Pia; Simpson, Michael A; Connell, Fiona C; Steward, Colin G et al.

Part of Nature Genetics, 2011.

DOI for Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome).

Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis.

Calvo, Charles-Félix; Fontaine, Romain H; Soueid, Jihane; Tammela, Tuomas et al.

Part of Genes & Development, 2011.

DOI for Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis.

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.

Tammela, Tuomas; Zarkada, Georgia; Nurmi, Harri; Jakobsson, Lars et al.

Part of Nature Cell Biology, 2011.

DOI for VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.

EphB-ephrin-B2 interactions are required for thymus migration during organogenesis.

Foster, Katie E; Gordon, Julie; Cardenas, Kim; Veiga-Fernandes, Henrique et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2010.

DOI for EphB-ephrin-B2 interactions are required for thymus migration during organogenesis.

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.

Wang, Yingdi; Nakayama, Masanori; Pitulescu, Mara E; Schmidt, Tim S et al.

Part of Nature, 2010.

DOI for Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.

Lymphatic dysfunction, not aplasia, underlies Milroy disease.

Mellor, Russell H; Hubert, Charlotte E; Stanton, Anthony W B; Tate, Naomi et al.

Part of Microcirculation, 2010.

DOI for Lymphatic dysfunction, not aplasia, underlies Milroy disease.

Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.

Bazigou, Eleni; Xie, Sherry; Chen, Chun; Weston, Anne et al.

Part of Developmental Cell, 2009.

DOI for Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.

Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.

Haiko, Paula; Mäkinen, Taija; Keskitalo, Salla; Taipale, Jussi et al.

Part of Molecular and Cellular Biology, 2008.

DOI for Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.

Lymphangiogenesis in development and disease.

Mäkinen, Taija; Alitalo, Kari

Part of Novartis Foundation symposium, 2007.

Lymphatic vasculature: a molecular perspective.

Hosking, Brett; Mäkinen, Taija

Part of Bioessays, 2007.

DOI for Lymphatic vasculature: a molecular perspective.

Molecular mechanisms of lymphatic vascular development.

Mäkinen, Taija; Norrmén, C; Petrova, T V

Part of Cellular and Molecular Life Sciences (CMLS), 2007.

DOI for Molecular mechanisms of lymphatic vascular development.

EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord.

Kadison, Stephanie R; Mäkinen, Taija; Klein, Rüdiger; Henkemeyer, Mark et al.

Part of Journal of Neuroscience, 2006.

DOI for EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord.

Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.

Karpanen, Terhi; Wirzenius, Maria; Mäkinen, Taija; Veikkola, Tanja et al.

Part of American Journal of Pathology, 2006.

DOI for Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.

Regulation of lymphangiogenesis--from cell fate determination to vessel remodeling.

Karpanen, Terhi; Mäkinen, Taija

Part of Experimental Cell Research, 2006.

DOI for Regulation of lymphangiogenesis--from cell fate determination to vessel remodeling.

Neural guidance molecules regulate vascular remodeling and vessel navigation.

Eichmann, Anne; Mäkinen, Taija; Alitalo, Kari

Part of Genes & Development, 2005.

DOI for Neural guidance molecules regulate vascular remodeling and vessel navigation.

PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.

Mäkinen, Taija; Adams, Ralf H; Bailey, John; Lu, Qiang et al.

Part of Genes & Development, 2005.

DOI for PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.

Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.

Wang, Hsei-Wei; Trotter, Matthew W B; Lagos, Dimitrios; Bourboulia, Dimitra et al.

Part of Nature Genetics, 2004.

DOI for Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.

Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis.

He, Yulong; Rajantie, Iiro; Ilmonen, Maritta; Mäkinen, Taija et al.

Part of Cancer Research, 2004.

DOI for Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis.

Vegfc is required for vascular development and endoderm morphogenesis in zebrafish.

Ober, Elke A; Olofsson, Birgitta; Mäkinen, Taija; Jin, Suk-Won et al.

Part of EMBO Reports, 2004.

DOI for Vegfc is required for vascular development and endoderm morphogenesis in zebrafish.

Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function.

Veikkola, Tanja; Lohela, Marja; Ikenberg, Kristian; Mäkinen, Taija et al.

Part of The FASEB Journal, 2003.

DOI for Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function.

Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites

Dixelius, Johan; Mäkinen, Taija; Wirzenius, Maria; Karkkainen, Marika J. et al.

Part of Journal of Biological Chemistry, p. 40973-40979, 2003.

DOI for Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites

Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites

Dixelius, Johan; Mäkinen, Taija; Wirzenius, Maria; Karkkainen, Marika J. et al.

Part of J Biol Chem, p. 40973-, 2003.

Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea.

Kubo, Hajime; Cao, Renhai; Brakenhielm, Ebba; Mäkinen, Taija et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2002.

DOI for Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea.

Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.

Petrova, Tatiana V; Mäkinen, Taija; Mäkelä, Tomi P; Saarela, Janna et al.

Part of EMBO Journal, 2002.

Lymphatic endothelium: a new frontier of metastasis research.

Karkkainen, Marika J; Mäkinen, Taija; Alitalo, Kari

Part of Nature Cell Biology, 2002.

DOI for Lymphatic endothelium: a new frontier of metastasis research.

[Lymphatic growth factors play a part in metastasis formation].

Mäkinen, Taija

Part of Duodecim, 2002.

Molecular mechanisms of lymphangiogenesis.

Mäkinen, Taija; Alitalo, K

Part of Cold Spring Harbor Symposia on Quantitative Biology, 2002.

Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.

Mäkinen, Taija; Jussila, L; Veikkola, T; Karpanen, T et al.

Part of Nature Medicine, 2001.

DOI for Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3.

Mäkinen, Taija; Veikkola, T; Mustjoki, S; Karpanen, T et al.

Part of EMBO Journal, 2001.

DOI for Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3.

Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice.

Veikkola, T; Jussila, L; Mäkinen, Taija; Karpanen, T et al.

Part of EMBO Journal, 2001.

DOI for Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice.

Monoclonal antibodies to vascular endothelial growth factor-D block its interactions with both VEGF receptor-2 and VEGF receptor-3.

Achen, M G; Roufail, S; Domagala, T; Catimel, B et al.

Part of European Journal of Biochemistry, 2000.

Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1.

Mäkinen, Taija; Olofsson, B; Karpanen, T; Hellman, U et al.

Part of Journal of Biological Chemistry, 1999.

Effect of inflammatory cytokines on the expression of the vascular endothelial growth factor-C.

Narko, K; Enholm, B; Mäkinen, Taija; Ristimäki, A

Part of International journal of experimental pathology (Print), 1999.

Endothelial growth factor receptors in human fetal heart.

Partanen, T A; Mäkinen, Taija; Arola, J; Suda, T et al.

Part of Circulation, 1999.

Signaling via vascular endothelial growth factor receptors.

Petrova, T V; Mäkinen, Taija; Alitalo, K

Part of Experimental Cell Research, 1999.

DOI for Signaling via vascular endothelial growth factor receptors.

Vascular endothelial growth factor receptor-3.

Taipale, J; Mäkinen, Taija; Arighi, E; Kukk, E et al.

Part of Current Topics in Microbiology and Immunology, 1999.

Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1.

Wise, L M; Veikkola, T; Mercer, A A; Savory, L J et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 1999.

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4).

Achen, M G; Jeltsch, M; Kukk, E; Mäkinen, Taija et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 1998.